Malamug Lou Rose, Karnchanasorn Rudruidee, Samoa Raynald, Chiu Ken C
Department of Clinical Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA ; Division of Endocrinology, Metabolism and Nutrition, Department of Internal Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Scientifica (Cairo). 2014;2014:870165. doi: 10.1155/2014/870165. Epub 2014 Mar 25.
Infection, for example, Helicobacter pylori (H. pylori), has been thought to play a role in the pathogenesis of type 2 diabetes mellitus (T2DM). Our aim was to determine the role of H. pylori infection in glucose metabolism in an American cohort. We examined data from 4,136 non-Hispanic white (NHW), non-Hispanic black (NHB), and Mexican Americans (MA) aged 18 and over from the NHANES 1999-2000 cohort. We calculated the odds ratios for states of glucose tolerance based on the H. pylori status. We calculated and compared homeostatic model assessment insulin resistance (HOMA-IR) and beta cell function (HOMA-B) in subjects without diabetes based on the H. pylori status. The results were adjusted for age, body mass index (BMI), poverty index, education, alcohol consumption, tobacco use, and physical activity. The H. pylori status was not a risk factor for abnormal glucose tolerance. After adjustment for age and BMI and also adjustment for all covariates, no difference was found in either HOMA-IR or HOMA-B in all ethnic and gender groups except for a marginally significant difference in HOMA-IR in NHB females. H. pylori infection was not a risk factor for abnormal glucose tolerance, nor plays a major role in insulin resistance or beta cell dysfunction.
例如，感染幽门螺杆菌（H. pylori）被认为在2型糖尿病（T2DM）的发病机制中起作用。我们的目的是确定在美国队列中幽门螺杆菌感染在葡萄糖代谢中的作用。我们检查了来自1999 - 2000年美国国家健康与营养检查调查（NHANES）队列中4136名18岁及以上的非西班牙裔白人（NHW）、非西班牙裔黑人（NHB）和墨西哥裔美国人（MA）的数据。我们根据幽门螺杆菌感染状况计算了糖耐量状态的比值比。我们根据幽门螺杆菌感染状况计算并比较了无糖尿病受试者的稳态模型评估胰岛素抵抗（HOMA - IR）和β细胞功能（HOMA - B）。结果针对年龄、体重指数（BMI）、贫困指数、教育程度、饮酒、吸烟和身体活动进行了调整。幽门螺杆菌感染状况不是糖耐量异常的危险因素。在调整年龄和BMI以及所有协变量后，除了NHB女性的HOMA - IR有轻微显著差异外，所有种族和性别组的HOMA - IR或HOMA - B均未发现差异。幽门螺杆菌感染不是糖耐量异常的危险因素，在胰岛素抵抗或β细胞功能障碍中也不起主要作用。
