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米槁提取物通过调节肠道微生物群预防小鼠糖尿病。

Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota.

机构信息

First Affiliated Hospital of Hainan Medical University, Haikou 571199, China.

Department of Biochemistry and Molecular Biology, Hainan Medical University, Haikou 571101, China.

出版信息

J Diabetes Res. 2018 Jun 4;2018:4230590. doi: 10.1155/2018/4230590. eCollection 2018.

DOI:10.1155/2018/4230590
PMID:29967794
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6008625/
Abstract

Recently, the role of gut microbiota in the development of obesity and type 2 diabetes mellitus (T2DM) has been highlighted. We performed an 8-week administration protocol on T2DM (C57BL/6J db-/db-) mice and fecal samples were collected. Comparisons of fecal bacterial communities were performed between db-/db- mice and normal mice (DB/DB) and between the db-/db mice treated and untreated with AOE using next-generation sequencing technology. Our results showed that the db-/db-AOE group had improved glycemic control and renal function compared with the db-/db-HO group. Compared with the db-/db-HO group, AOE administration resulted in significantly increased ratio of Bacteroidetes-to-Firmicutes in db-/db- mice. In addition, the abundance of was significantly increased, while was significantly suppressed in the db-/db-AOE group compared with the db-/db-HO group. Our data suggest that AOE treatment decreased blood glucose levels and significantly reduced damage of renal pathology in the T2DM mice by modulating gut microbiota composition.

摘要

最近，肠道微生物群在肥胖和 2 型糖尿病（T2DM）的发展中的作用受到了重视。我们对 T2DM（C57BL/6J db-/db-）小鼠进行了为期 8 周的给药方案，收集粪便样本。使用下一代测序技术，比较了 db-/db-小鼠和正常小鼠（DB/DB）之间以及用 AOE 处理和未处理的 db-/db-小鼠之间的粪便细菌群落。我们的结果表明，与 db-/db-HO 组相比，db-/db-AOE 组的血糖控制和肾功能得到改善。与 db-/db-HO 组相比，AOE 给药导致 db-/db-小鼠中厚壁菌门与拟杆菌门的比例显著增加。此外，与 db-/db-HO 组相比，db-/db-AOE 组中的 丰度显著增加，而 丰度显著受到抑制。我们的数据表明，AOE 治疗通过调节肠道微生物群落组成降低了 T2DM 小鼠的血糖水平，并显著减轻了肾脏病理损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30cb/6008625/4c4d3401f25b/JDR2018-4230590.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30cb/6008625/5b70cf0f8a62/JDR2018-4230590.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30cb/6008625/b5cc8fba3772/JDR2018-4230590.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30cb/6008625/13152e940aa0/JDR2018-4230590.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30cb/6008625/4c4d3401f25b/JDR2018-4230590.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30cb/6008625/5b70cf0f8a62/JDR2018-4230590.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30cb/6008625/b5cc8fba3772/JDR2018-4230590.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30cb/6008625/13152e940aa0/JDR2018-4230590.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30cb/6008625/4c4d3401f25b/JDR2018-4230590.005.jpg

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