Chen Hao, Fang Yu, Li Wenbo, Orlando Roy C, Shaheen Nicholas, Chen Xiaoxin Luke
Cancer Research Program; JLC-BBRI; North Carolina Central University; Durham, NC USA.
Department of Thoracic and Cardiovascular Surgery; The First Affiliated Hospital of Chongqing Medical University; Chongqing, China.
Tissue Barriers. 2013 Dec 1;1(5):e27463. doi: 10.4161/tisb.27463. Epub 2013 Dec 10.
The stratified squamous epithelium of the esophagus forms a tight protective barrier. Defects of the barrier function contribute to gastroesophageal reflux disease (GERD), which is manifested as damage to the esophageal epithelium due to exposure to the gastrointestinal refluxate. In this review, we discuss the involvement of NFkB and Nrf2 in esophageal epithelial barrier function. Understanding these molecular pathways in the esophagus may help us develop therapeutic strategies to improve clinical outcomes in patients with GERD.
食管的复层鳞状上皮形成紧密的保护屏障。屏障功能缺陷会导致胃食管反流病（GERD），其表现为食管上皮因暴露于胃肠反流物而受损。在本综述中，我们讨论了NFkB和Nrf2在食管上皮屏障功能中的作用。了解食管中的这些分子途径可能有助于我们制定治疗策略，以改善GERD患者的临床结局。
