Research and Development Center for Fine Chemicals, State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China.
Molecules. 2013 Jan 22;18(1):1325-36. doi: 10.3390/molecules18011325.
The current study targets the chemical constituents of Caesalpinia decapetala (Roth) Alston and investigates the bioactivities of the isolated compounds. Fourteen known compounds were isolated using column chromatography, and structural identification was performed by physical and spectral analyses. The biological activities of the compounds were also evaluated by 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2,2-diphenlyl-1-picrylhydrazyl (DPPH) assays. Emodin (6), baicalein (9), and apigenin (12) displayed antitumor activities against the MGC-803 cell line, while quercetin (2), rutin (5), baicalein (9), and epicatechin (13) showed stronger DPPH scavenging activities compared with ascorbic acid. Andrographolide (1), quercetin (2), bergenin (4), rutin (5), emodin (6), betulin (7), baicalein (9), polydatin (10), salicin (11), and apigenin (12), were obtained from C. decapetala (Roth) Alston for the first time.
本研究以罗伞树（Caesalpinia decapetala (Roth) Alston）的化学成分作为研究对象，对分离得到的化合物的生物活性进行了研究。通过柱层析分离得到了 14 个已知化合物，并通过物理和光谱分析进行了结构鉴定。还通过 3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐（MTT）和 2,2-二苯基-1-苦基肼（DPPH）测定法评估了化合物的生物活性。大黄素（6）、黄芩素（9）和芹菜素（12）对 MGC-803 细胞系表现出抗肿瘤活性，而槲皮素（2）、芦丁（5）、黄芩素（9）和表儿茶素（13）的 DPPH 清除活性强于抗坏血酸。此外，从罗伞树（Caesalpinia decapetala (Roth) Alston）中首次分离得到了穿心莲内酯（1）、槲皮素（2）、β-谷甾醇（4）、芦丁（5）、大黄素（6）、白桦脂醇（7）、黄芩素（9）、虎杖苷（10）、水杨苷（11）和芹菜素（12）。
