伊朗急性胃肠炎儿童中的人博卡病毒
Human Bocavirus in Iranian children with acute gastroenteritis.
作者信息
Monavari Seyed Hamidreza, Noorbakhsh Samileh, Mollaie Hamidreza, Fazlalipour Mehdi, Abedi Kiasari Bahman
机构信息
PhD, Associate professor, Department of Virology and Anti-Microbial Resistance Research Center, Tehran University of Medical Sciences, Hemmat Highway, Tehran, Iran.
Professor of Pediatric Infectious Diseases, Research Center of Pediatric Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran. samileh_noorbakhsh @yahoo.com.
出版信息
Med J Islam Repub Iran. 2013 Aug;27(3):127-31.
BACKGROUND
Human Bocavirus (HBoV) infection is of worldwide distribution. There is increasing evidencethat HBoV is pathogenic for the human gastroenteric tract. However, less data are available on the role of HBoVin gastroenteritis. The present study was aimed to determine the prevalence of HBoV in children with gastroenteritis.
METHODS
Real-time PCR TaqMan was used to screen 200 stool specimens that had been referred to the virologylaboratory for HBoV evaluation. All of samples were collected on viral transport media.
RESULTS
Of the 200 stool samples analyzed, 16 (8%) were positive for HBoV. Human Bocavirus positive samplesfrom patients aged between 1 to 5 years with acute gastroenteritis infection suggest a minor role of HBoVin gastroenteritis (p=0.0001).
CONCLUSION
The study showed a high prevalence of human Bocavirus in young children with acute gastroenteritisdiseases in Iran, suggesting that HBoV play a role in the pathogenesis of gastroenteritis.
背景
人博卡病毒（HBoV）感染在全球范围内均有分布。越来越多的证据表明，HBoV对人类胃肠道具有致病性。然而，关于HBoV在胃肠炎中作用的数据较少。本研究旨在确定胃肠炎患儿中HBoV的流行情况。
方法
采用实时荧光定量PCR TaqMan技术对200份送检至病毒学实验室进行HBoV评估的粪便标本进行筛查。所有样本均采集于病毒运输培养基上。
结果
在分析的200份粪便样本中，16份（8%）HBoV呈阳性。1至5岁急性胃肠炎感染患者的人博卡病毒阳性样本表明HBoV在胃肠炎中的作用较小（p = 0.0001）。
结论
该研究表明，伊朗急性胃肠炎患儿中人博卡病毒的感染率较高，提示HBoV在胃肠炎发病机制中发挥作用。
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