Systems Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Center for Molecular Medicine, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Biochem Biophys Res Commun. 2014 Jul 11;449(4):384-5. doi: 10.1016/j.bbrc.2014.04.144. Epub 2014 May 1.
Entry of mitochondrial calcium is believed to play an essential role in regulating bioenergetics and initiating cell death pathways. We have recently described a mouse model lacking MCU expression. Surprisingly, these mice are viable and the cells and tissues from these animals do not exhibit any marked protection from cell death. Here, we discuss our findings as well as potential explanations for some of the more unexpected results.
线粒体钙内流被认为在调节生物能量和启动细胞死亡途径方面发挥着重要作用。我们最近描述了一种缺乏 MCU 表达的小鼠模型。令人惊讶的是，这些小鼠是存活的，并且这些动物的细胞和组织没有表现出任何明显的对细胞死亡的保护作用。在这里，我们讨论我们的发现以及对一些更意外结果的可能解释。
