青少年焦虑症状变化的遗传和环境原因：多评估者双生子研究。
Genetic and environmental causes of variation in adolescent anxiety symptoms: a multiple-rater twin study.
机构信息
Centre for Child and Adolescent Mental Health, RBUP Eastern and Southern Norway, P.O. Box 4623, Nydalen, 0405 Oslo, Norway.
Centre for Child and Adolescent Mental Health, RBUP Eastern and Southern Norway, P.O. Box 4623, Nydalen, 0405 Oslo, Norway; Department of Psychology, Faculty of Social Sciences, University of Oslo, P.O. Box 1094, Blindern, 0317 Oslo, Norway.
出版信息
J Anxiety Disord. 2014 May;28(4):363-71. doi: 10.1016/j.janxdis.2014.04.003. Epub 2014 Apr 15.
Heritability estimates for adolescent anxiety vary across studies, partly depending on who is rating the symptoms. The goal of our study was to estimate genetic and environmental influences using a multi-informant design with responses from a population-based sample of adolescent twins, their mothers and their fathers (N=1394 families). Results from multivariate biometrical modeling indicated quantitative, but no qualitative sex differences in etiology. The best fitting model was an AE Common Pathway model, defining anxiety as a latent factor common to all informants. This model offers error free estimates of genetic and environmental influences explaining the latent factor variance. Variation in the latent factor was highly genetic, with heritability estimates of 65% for boys and 74% for girls. Non-shared environmental effects explained the remaining variance. In addition, there were significant rater-specific genetic and environmental effects for both sexes. The observed rater differences underline the importance of using several informants when studying adolescent anxiety.
青少年焦虑症的遗传度估计因研究而异，部分原因取决于评估症状的人。我们的研究目的是使用多信息源设计，从青少年双胞胎及其母亲和父亲的基于人群的样本中（N=1394 个家庭），利用响应来估计遗传和环境影响。多元生物计量建模的结果表明，在病因学方面存在定量但没有定性的性别差异。最适合的模型是 AE 共同途径模型，将焦虑定义为所有信息提供者共有的潜在因素。该模型提供了遗传和环境影响的无误差估计，这些影响解释了潜在因素的方差。潜在因素的变化高度受遗传影响，男孩的遗传度估计值为 65%，女孩的遗传度估计值为 74%。非共享环境效应解释了剩余的方差。此外，两性都存在显著的特定于评估者的遗传和环境效应。观察到的评估者差异强调了在研究青少年焦虑症时使用多个信息提供者的重要性。
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