Timmermans J P, Scheuermann D W, Stach W, Adriaensen D, De Groodt-Lasseel M H, Polak J M
Institute of Histology and Microscopic Anatomy, University of Antwerp, Belgium.
Cell Tissue Res. 1989 Nov;258(2):331-7. doi: 10.1007/BF00239453.
In the small intestine of the pig, neuromedin U (NMU)-immunoreactivity was mainly confined to the nerve plexus of the inner submucosal and mucosal regions. After colchicine treatment, a high number of immunoreactive nerve cell bodies was observed in the plexus submucosus internus (Meissner), whereas only a low number was found in the plexus submucosus externus (Schabadasch). The plexus myentericus as well as the aganglionic nerve meshworks in the circular and longitudinal smooth muscle layers almost completely lacked NMU-immunoreactivity. Double-labeling experiments demonstrated the occurrence of distinct NMU-containing neuron populations in the plexus submucosus internus: (1) relatively large type-II neurons revealing immunoreactivity for NMU and calcitonin gene-related peptide (CGRP) and/or substance P (SP); (2) a group of small NMU- and SP-immunoreactive neurons; (3) a relatively low number of small neurons displaying immunoreactivity for NMU but not for SP. Based on its distributional pattern, it is concluded that NMU plays an important role in the regulation and control of mucosal functions.
在猪的小肠中，神经介素U（NMU）免疫反应性主要局限于黏膜下层内侧和黏膜区域的神经丛。秋水仙碱处理后，在内侧黏膜下神经丛（迈斯纳神经丛）中观察到大量免疫反应性神经细胞体，而在外侧黏膜下神经丛（沙巴达施神经丛）中仅发现少量。肌间神经丛以及环形和纵行平滑肌层中的无神经节神经网几乎完全缺乏NMU免疫反应性。双重标记实验表明，内侧黏膜下神经丛中存在不同的含NMU神经元群体：（1）相对较大的II型神经元，对NMU和降钙素基因相关肽（CGRP）及/或P物质（SP）呈免疫反应性；（2）一组小的NMU和SP免疫反应性神经元；（3）相对少量的小神经元，对NMU呈免疫反应性，但对SP无反应。根据其分布模式，得出结论：NMU在黏膜功能的调节和控制中起重要作用。
