Aqil Barina, Green Linda K, Lai Syeling
MD; Department of Pathology, Michael E. DeBakey VA Medical Center, 2002 Holcombe Blvd, Houston, TX, 77030, USA; phone: 713 794 7246; fax: 713 794 7657;
Ann Clin Lab Sci. 2014 Spring;44(2):217-21.
Primary angiosarcoma of the spleen is a rare neoplasm arising from endothelial cells. It is an aggressive neoplasm with a poor prognosis. We report a case of 61-year-old Caucasian man who presented with shortness of breath, anemia, leukocytosis, and thrombocytopenia. Ultrasound Sonogram (US) and Computed Tomography (CT) scans revealed a massively enlarged spleen with numerous enhancing hypodense lesions. The spleen was adherent to the omentum, retroperitoneum, and tail of the pancreas. Image-guided Fine Needle Aspiration (FNA) revealed an atypical spindle cell lesion. Resection of the spleen and attached tail of pancreas was performed. Histological examination and immunohistochemical studies revealed a diffuse vascular malignant neoplasm with features of angiosarcoma. The patient appeared disease free after resection. He died within 5 months of unknown etiology.
脾脏原发性血管肉瘤是一种罕见的起源于内皮细胞的肿瘤。它是一种侵袭性肿瘤，预后较差。我们报告一例61岁的白种男性患者，表现为呼吸急促、贫血、白细胞增多和血小板减少。超声检查（US）和计算机断层扫描（CT）显示脾脏大量肿大，有许多强化的低密度病变。脾脏与网膜、腹膜后和胰尾粘连。影像引导下细针穿刺抽吸活检（FNA）显示为非典型梭形细胞病变。进行了脾脏及附着的胰尾切除术。组织学检查和免疫组化研究显示为具有血管肉瘤特征的弥漫性血管恶性肿瘤。患者术后无疾病表现。他在5个月内死于不明病因。
