Ding Yi, Griffin Jennifer E, Raghavan Meera, Xu Hairong, Henderson-Jackson Evita, Bui Marilyn M
Director of Analytic Microscopy Core, Director of Cytopathology Fellowship Program, Associate Member/Professor, Departments of Anatomic Pathology, Sarcoma and Chemical Biology and Molecular Medicine Program, Moffitt Cancer Center, Departments of Oncological Sciences, Cell Biology and Pathology, Morsani College of Medicine at University of South Florida, 12902 Magnolia Dr., Tampa, FL 33612, USA; phone: 813 745 4940; fax: 813 745 5970; e mail: Marilyn.
Ann Clin Lab Sci. 2014 Spring;44(2):222-7.
Tenosynovial giant cell tumors are a group of neoplastic disorders that involve synovium-lined tendon sheaths, synovial joints, and adjacent soft tissue. They are divided into localized and diffuse subtypes. TSGCTs have well-established clinical and histological diagnostic criteria; however, the subtypes and nomenclature can be confusing. They also pose diagnostic challenges when they occur in atypical locations or without multinucleated giant cells. With the possibility for systemic targeted therapy in relapsing pigmented villonodular tenosynovitis and diffuse-type giant cell tumor, accurate diagnosis and subtyping of TSGCTs is increasingly important. We report two cases of TSGCTs in order to elucidate the diagnostic nomenclature, clinicopathological features, differential diagnosis, and diagnostic pitfalls. Recent advancements in the pathogenesis and targeted therapy of TSGCTs are also discussed.
腱鞘巨细胞瘤是一组涉及滑膜衬里的腱鞘、滑膜关节及相邻软组织的肿瘤性疾病。它们分为局限性和弥漫性亚型。腱鞘巨细胞瘤有公认的临床和组织学诊断标准；然而，亚型和命名可能令人困惑。当它们发生在非典型部位或没有多核巨细胞时，也会带来诊断挑战。鉴于复发性色素沉着绒毛结节性滑膜炎和弥漫型巨细胞瘤有进行全身靶向治疗的可能性，腱鞘巨细胞瘤的准确诊断和亚型分类变得越来越重要。我们报告两例腱鞘巨细胞瘤病例，以阐明诊断命名、临床病理特征、鉴别诊断及诊断陷阱。还讨论了腱鞘巨细胞瘤发病机制和靶向治疗的最新进展。
