Nagpal Neha, Kulshreshtha Ritu
RNA-II Lab, Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi New Delhi, India.
Front Genet. 2014 Apr 23;5:99. doi: 10.3389/fgene.2014.00099. eCollection 2014.
Specific microRNAs have emerged as key players in disease biology by playing crucial role in disease development and progression. This review draws attention to one such microRNA, miR-191 that has been recently reported to be abnormally expressed in several cancers (>20) and various other diseases like diabetes-type 2, Crohn' s, pulmonary hypertension, and Alzheimer' s. It regulates important cellular processes such as cell proliferation, differentiation, apoptosis, and migration by targeting important transcription factors, chromatin remodelers, and cell cycle associated genes. Several studies have demonstrated it to be an excellent biomarker for cancer diagnosis and prognosis leading to two patents already in its kitty. In this first review we summarize the current knowledge of the regulation, functions and targets of miR-191 and discuss its potential as a promising disease biomarker and therapeutic target.
特定的微小RNA已成为疾病生物学中的关键角色，在疾病发展和进程中发挥着至关重要的作用。本综述关注的是一种这样的微小RNA，即miR-191，最近有报道称它在多种癌症（超过20种）以及其他各种疾病如2型糖尿病、克罗恩病、肺动脉高压和阿尔茨海默病中异常表达。它通过靶向重要的转录因子、染色质重塑因子和细胞周期相关基因来调节重要的细胞过程，如细胞增殖、分化、凋亡和迁移。多项研究表明它是癌症诊断和预后的优秀生物标志物，已经获得了两项专利。在这篇首次综述中，我们总结了目前关于miR-191的调控、功能和靶点的知识，并讨论了它作为有前景的疾病生物标志物和治疗靶点的潜力。
