Verstuyf A, Sobis H, Vandeputte M
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.
Int J Cancer. 1989 Nov 15;44(5):879-84. doi: 10.1002/ijc.2910440522.
A post-gestational rat choriocarcinoma has been studied for its immunological and morphological characteristics. The tumor can be transplanted in syngeneic (WKA/H rats) as well as in allogeneic rats (BN, R/A). Even after immunization of the allogeneic hosts with tissues of the WKA/H rats, the development of the tumor was not inhibited. This neoplasm is composed of giant cells, surrounding spaces filled with blood, and of proliferating cytotrophoblasts. Ultrastructurally, these cells are very similar to those found in normal rat placenta. In some rats lung metastases were also observed. The tumor is hormonally active as demonstrated by proliferation of and secretions from the mammary glands in tumor-bearing animals and by the presence of delta 5-3 beta-hydroxysteroid dehydrogenase in the giant cells of the neoplasms. These 2 findings indicate that the rat choriocarcinoma cells secrete lactogen and might produce progesterone, like cells of rat placenta. All the described features of this tumor point to its similarity to human choriocarcinoma.
对一只妊娠后期大鼠的绒毛膜癌进行了免疫和形态学特征研究。该肿瘤可移植到同基因（WKA/H大鼠）以及异基因大鼠（BN、R/A）体内。即使在用WKA/H大鼠组织免疫异基因宿主后，肿瘤的生长也未受到抑制。这种肿瘤由巨细胞、充满血液的周围间隙以及增殖的细胞滋养层细胞组成。在超微结构上，这些细胞与正常大鼠胎盘细胞非常相似。在一些大鼠中还观察到了肺转移。该肿瘤具有激素活性，表现为荷瘤动物乳腺的增殖和分泌，以及肿瘤巨细胞中存在δ5-3β-羟基类固醇脱氢酶。这两个发现表明，大鼠绒毛膜癌细胞分泌催乳素，可能像大鼠胎盘细胞一样产生孕酮。该肿瘤所描述的所有特征都表明它与人类绒毛膜癌相似。
