Tomita K
Yakugaku Zasshi. 1989 Jul;109(7):439-59. doi: 10.1248/yakushi1947.109.7_439.
Since the discovery of the right-handed double helical structure of deoxyribonucleic acid by Watson and Crick in 1953, many pieces of detailed nucleic acid structural information involving ribonucleic acid have been elucidated and this review describes the results of the X-ray structural studies of nucleic acids and their constituents carried out in my laboratory. In the latter half the nucleic acid-protein interaction mechanism was also discussed on the basis of the molecular model of the stacking interaction between base and aromatic amino acid side chains. The structure-function relationship of ribonuclease T1.guanosine monophosphate complex was used as an example.
自1953年沃森和克里克发现脱氧核糖核酸的右手双螺旋结构以来，许多涉及核糖核酸的详细核酸结构信息已被阐明，本综述描述了在我的实验室中进行的核酸及其成分的X射线结构研究结果。后半部分还基于碱基与芳香族氨基酸侧链之间堆积相互作用的分子模型讨论了核酸-蛋白质相互作用机制。以核糖核酸酶T1-鸟苷单磷酸复合物的结构-功能关系为例。
