The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells.
作者信息
Xu Tongfu, Yang Liu, Yan Cheng, Wang Xiaoxia, Huang Ping, Zhao Feng, Zhao Liyun, Zhang Mingliang, Jia Weiping, Wang Xiangdong, Liu Yong
机构信息
Department of Cell Biology, Shandong University School of Medicine, 44 Wenhua Road West, Jinan, Shandong 250012, China.
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
出版信息
Cell Res. 2014 Sep;24(9):1137-40. doi: 10.1038/cr.2014.55. Epub 2014 May 6.
Abstract
摘要
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The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells.肌醇需求酶1α- X盒结合蛋白1信号通路调节代谢应激诱导的胰腺β细胞代偿性增殖。
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本文引用的文献
1
Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.IRE1α 通过 XBP1s-PPARα 轴信号调节肝饥饿诱导的代谢适应性程序。
Nat Commun. 2014 Mar 27;5:3528. doi: 10.1038/ncomms4528.
2
Endoplasmic reticulum stress and type 2 diabetes.内质网应激与 2 型糖尿病。
Annu Rev Biochem. 2012;81:767-93. doi: 10.1146/annurev-biochem-072909-095555. Epub 2012 Mar 23.
3
The unfolded protein response: controlling cell fate decisions under ER stress and beyond.未折叠蛋白反应：在 ER 应激及其他情况下控制细胞命运决定。
Nat Rev Mol Cell Biol. 2012 Jan 18;13(2):89-102. doi: 10.1038/nrm3270.
4
Transgenic expression of entire hepatitis B virus in mice induces hepatocarcinogenesis independent of chronic liver injury.转基因表达完整的乙型肝炎病毒在小鼠中诱导肝癌发生，而不依赖于慢性肝损伤。
PLoS One. 2011;6(10):e26240. doi: 10.1371/journal.pone.0026240. Epub 2011 Oct 12.
5
Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion.IRE1α 和 XBP1 调控的未折叠蛋白反应在胰岛素原加工和胰岛素分泌中的双重和相反作用。
Proc Natl Acad Sci U S A. 2011 May 24;108(21):8885-90. doi: 10.1073/pnas.1105564108. Epub 2011 May 9.
6
IRE1α disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level.IRE1α 缺失导致外分泌组织组织学异常、血糖水平升高和血清免疫球蛋白水平降低。
PLoS One. 2010 Sep 27;5(9):e13052. doi: 10.1371/journal.pone.0013052.
7
Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis.持续产生拼接的 X 盒结合蛋白 1（XBP1）可诱导胰腺β细胞功能障碍和凋亡。
Diabetologia. 2010 Jun;53(6):1120-30. doi: 10.1007/s00125-010-1699-7. Epub 2010 Mar 29.
8
A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells.RACK1 在调节胰岛β细胞葡萄糖刺激的 IRE1α 激活中起关键作用。
Sci Signal. 2010 Jan 26;3(106):ra7. doi: 10.1126/scisignal.2000514.
9
IRE1alpha controls cyclin A1 expression and promotes cell proliferation through XBP-1.IRE1α 通过 XBP-1 控制细胞周期蛋白 A1 的表达并促进细胞增殖。
Cell Stress Chaperones. 2010 Sep;15(5):497-508. doi: 10.1007/s12192-009-0163-4. Epub 2009 Dec 15.
10
The role for endoplasmic reticulum stress in diabetes mellitus.内质网应激在糖尿病中的作用。
Endocr Rev. 2008 Feb;29(1):42-61. doi: 10.1210/er.2007-0015. Epub 2007 Nov 29.
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