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The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells.

作者信息

Xu Tongfu, Yang Liu, Yan Cheng, Wang Xiaoxia, Huang Ping, Zhao Feng, Zhao Liyun, Zhang Mingliang, Jia Weiping, Wang Xiangdong, Liu Yong

机构信息

Department of Cell Biology, Shandong University School of Medicine, 44 Wenhua Road West, Jinan, Shandong 250012, China.

Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

出版信息

Cell Res. 2014 Sep;24(9):1137-40. doi: 10.1038/cr.2014.55. Epub 2014 May 6.

Abstract
摘要

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本文引用的文献

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Endoplasmic reticulum stress and type 2 diabetes.
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Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion.
Proc Natl Acad Sci U S A. 2011 May 24;108(21):8885-90. doi: 10.1073/pnas.1105564108. Epub 2011 May 9.
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Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis.
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IRE1alpha controls cyclin A1 expression and promotes cell proliferation through XBP-1.
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