Konstantinidis Theocharis, Cassimos Dimitrios, Gioka Theodora, Tsigalou Christina, Parasidis Theodoros, Alexandropoulou Ioanna, Nikolaidis Christos, Kampouromiti Georgia, Constantinidis Theodoros, Chatzimichael Athanasios, Panopoulou Maria
Regional Public Health Laboratory, Hellenic Center for Disease Control and Prevention, Alexandroupolis, Greece.
Paediatric Department, Medical School, Democritus University of Thrace, Komotini, Greece.
J Clin Lab Anal. 2015 May;29(3):169-74. doi: 10.1002/jcla.21746. Epub 2014 May 5.
To study the levels of procalcitonin (PCT) in patients with meningitis and control group and compare them with established markers of infection--such as C-reactive protein (CRP), high-sensitivity CRP, and WBC--in cerebrospinal fluid (CSF) and assess the possible discriminative role of PCT in the differential diagnosis of meningitis from other noninfectious diseases.
We studied CSF samples of patients from Intensive Care Unit, Internal Medicine, Neurology, Hematology, and Pediatric departments. The total number of patients included in the study was 58. The samples were divided into three groups: group 1 with bacterial meningitis (BM) central nervous system (n = 19); group 2 with viral meningitis (VM, n = 11); and group 3, control group, with noninfectious diseases (n = 28).
Values of PCT levels >0.5 ng/ml were considered as abnormal. In group 1, mean PCT levels were 4.714 ± 1.59 ng/ml. In group 2, all patients had PCT <0.5 ng/ml (0.1327 ± 0.03 ng/ml). In group 3, the mean PCT levels were <0.1 ng/ml.
PCT values in CSF can be very helpful in distinguishing BM from VM and other noninfectious diseases.
研究脑膜炎患者和对照组中降钙素原（PCT）的水平，并将其与脑脊液（CSF）中已有的感染标志物（如C反应蛋白（CRP）、高敏CRP和白细胞（WBC））进行比较，评估PCT在脑膜炎与其他非感染性疾病鉴别诊断中的可能判别作用。
我们研究了重症监护病房、内科、神经内科、血液科和儿科患者的脑脊液样本。纳入研究的患者总数为58例。样本分为三组：第1组为细菌性脑膜炎（BM）中枢神经系统感染（n = 19）；第2组为病毒性脑膜炎（VM，n = 11）；第3组为对照组，患有非感染性疾病（n = 28）。
PCT水平>0.5 ng/ml被视为异常。在第1组中，PCT平均水平为4.714±1.59 ng/ml。在第2组中，所有患者的PCT<0.5 ng/ml（0.1327±0.03 ng/ml）。在第3组中，PCT平均水平<0.1 ng/ml。
脑脊液中的PCT值在区分细菌性脑膜炎与病毒性脑膜炎及其他非感染性疾病方面非常有帮助。
