酵母中单价阳离子稳态的系统生物学：透明的贡献。

Systems biology of monovalent cation homeostasis in yeast: the translucent contribution.

作者信息

Ariño Joaquín, Aydar Ebru, Drulhe Samuel, Ganser Daniel, Jorrín Jesús, Kahm Matthias, Krause Falko, Petrezsélyová Silvia, Yenush Lynne, Zimmermannová Olga, van Heusden G Paul H, Kschischo Maik, Ludwig Jost, Palmer Chris, Ramos José, Sychrová Hana

机构信息

Institut de Biotecnologia i Biomedicina & Dept. Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain.

Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom.

出版信息

Adv Microb Physiol. 2014;64:1-63. doi: 10.1016/B978-0-12-800143-1.00001-4.

DOI:10.1016/B978-0-12-800143-1.00001-4

PMID:24797924

Abstract

Maintenance of monovalent cation homeostasis (mainly K(+) and Na(+)) is vital for cell survival, and cation toxicity is at the basis of a myriad of relevant phenomena, such as salt stress in crops and diverse human diseases. Full understanding of the importance of monovalent cations in the biology of the cell can only be achieved from a systemic perspective. Translucent is a multinational project developed within the context of the SysMO (System Biology of Microorganisms) initiative and focussed in the study of cation homeostasis using the well-known yeast Saccharomyces cerevisiae as a model. The present review summarize how the combination of biochemical, genetic, genomic and computational approaches has boosted our knowledge in this field, providing the basis for a more comprehensive and coherent vision of the role of monovalent cations in the biology of the cell.

摘要

维持单价阳离子稳态（主要是K⁺和Na⁺）对细胞存活至关重要，阳离子毒性是众多相关现象的基础，如作物盐胁迫和多种人类疾病。只有从系统的角度才能充分理解单价阳离子在细胞生物学中的重要性。Translucent是在SysMO（微生物系统生物学）计划背景下开展的一个跨国项目，专注于以著名的酿酒酵母为模型研究阳离子稳态。本综述总结了生化、遗传、基因组和计算方法的结合如何增进了我们在该领域的知识，为更全面、连贯地认识单价阳离子在细胞生物学中的作用提供了基础。