Ariño Joaquín, Ramos José, Sychrova Hana
Institut de Biotecnologia i Biomedicina and Departament de Bioquimica i Biologia Molecular, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
Departamento de Microbiología, Universidad de Córdoba, Córdoba, Spain.
Yeast. 2019 Apr;36(4):177-193. doi: 10.1002/yea.3355. Epub 2018 Oct 3.
Maintenance of proper intracellular concentrations of monovalent cations, mainly sodium and potassium, is a requirement for survival of any cell. In the budding yeast Saccharomyces cerevisiae, monovalent cation homeostasis is determined by the active extrusion of protons through the Pma1 H -ATPase (reviewed in another chapter of this issue), the influx and efflux of these cations through the plasma membrane transporters (reviewed in this chapter), and the sequestration of toxic cations into the vacuoles. Here, we will describe the structure, function, and regulation of the plasma membrane transporters Trk1, Trk2, Tok1, Nha1, and Ena1, which play a key role in maintaining physiological intracellular concentrations of Na , K , and H , both under normal growth conditions and in response to stress.
维持适当的细胞内单价阳离子浓度，主要是钠和钾，是任何细胞存活的必要条件。在出芽酵母酿酒酵母中，单价阳离子稳态由质子通过Pma1 H-ATP酶的主动排出（在本期另一章中综述）、这些阳离子通过质膜转运蛋白的流入和流出（在本章中综述）以及将有毒阳离子隔离到液泡中来决定。在这里，我们将描述质膜转运蛋白Trk1、Trk2、Tok1、Nha1和Ena1的结构、功能和调节，它们在正常生长条件下以及应对压力时，在维持细胞内Na、K和H的生理浓度方面发挥关键作用。
