Departamento de Química Orgánica y Centro Singular de Investigación en Química Biológica y Materiales Moleculares (CIQUS), Universidad de Santiago de Compostela, 15782 Santiago de Compostela (Spain) http://www.usc.es/gi1603/saa.
Angew Chem Int Ed Engl. 2014 Jun 2;53(23):5959-63. doi: 10.1002/anie.201400675. Epub 2014 May 5.
A novel synthesis of 2-vinyldihydropyrans and dihydro-1,4-oxazines (morpholine derivatives) from alkynals and alkynones has been developed. The cyclizations require a mild generation of catalytic ruthenium carbenes from terminal alkynes and (trimethylsilyl)diazomethane followed by trapping with carbonyl nucleophiles. Mechanistic aspects of the new cyclizations are discussed.
一种新颖的 2-乙烯基二氢吡喃和二氢-1,4-恶嗪（吗啡啉衍生物）的合成方法，是由炔醛和炔酮开发的。这些环化反应需要温和地从末端炔烃和（三甲基硅基）重氮甲烷生成催化钌卡宾，然后用羰基亲核试剂捕获。讨论了新的环化反应的机理方面。
