Tursi Antonio, Elisei Walter, Picchio Marcello, Brandimarte Giovanni
Gastroenterology Service, ASL BAT, Via Torino, 49, 76123, Andria, BT, Italy,
Int J Colorectal Dis. 2014 Aug;29(8):931-5. doi: 10.1007/s00384-014-1884-0. Epub 2014 May 7.
Colonic diverticulitis shows a high recurrence rate, but the role of faecal markers in predicting recurrence is unknown. The aim of this study was to investigate the role of faecal calprotectin (FC) in predicting recurrence of diverticulitis.
PATIENTS/METHODS: A prospective cohort study was performed on 54 patients suffering from acute uncomplicated diverticulitis (AUD) diagnosed by computerized tomography (CT). After remission, patients underwent to clinical follow-up every 2 months. After remission and during the follow-up, FC was analysed. Recurrence of diverticulitis was defined as return to our observation due to left lower-quadrant pain with or without other symptoms (e.g. fever), associated with leucocytosis and/or increased C-reactive protein (CRP). Presence of diverticulitis was confirmed by means of CT.
RESULTS/FINDINGS: The mean follow-up was 20 months (range 12-24 months). Forty-eight patients were available for the final evaluation, and six patients were lost to follow-up. During follow-up, increased FC was detected in 17 (35.4 %) patients and diverticulitis recurred in eight patients (16.7 %). Diverticulitis recurred in eight (16.7 %) patients: seven (87.5 %) patients showed increased FC during the follow-up, and only one (12.5 %) patient with recurrent diverticulitis did not show increased FC. Diverticulitis recurrence was strictly related to the presence of abnormal FC test during follow-up.
In the present prospective study, increased FC was found to be predictive of diverticulitis recurrence.
结肠憩室炎复发率较高，但粪便标志物在预测复发方面的作用尚不清楚。本研究旨在探讨粪便钙卫蛋白（FC）在预测憩室炎复发中的作用。
患者/方法：对54例经计算机断层扫描（CT）诊断为急性非复杂性憩室炎（AUD）的患者进行了一项前瞻性队列研究。缓解后，患者每2个月进行一次临床随访。缓解后及随访期间，对FC进行分析。憩室炎复发定义为因左下腹疼痛伴或不伴其他症状（如发热），伴有白细胞增多和/或C反应蛋白（CRP）升高而再次前来就诊。通过CT确认憩室炎的存在。
结果/发现：平均随访时间为20个月（范围12 - 24个月）。48例患者可进行最终评估，6例患者失访。随访期间，17例（35.4%）患者检测到FC升高，8例患者（16.7%）憩室炎复发。8例（16.7%）患者憩室炎复发：7例（87.5%）患者在随访期间FC升高，只有1例（12.5%）复发性憩室炎患者FC未升高。憩室炎复发与随访期间FC检测异常密切相关。
在本前瞻性研究中，发现FC升高可预测憩室炎复发。
