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[睾酮作用下不同年龄大鼠交感神经元细胞核中组蛋白和转录的变化]

[Changes in histones and transcription in the nuclei of sympathetic neurons in rats of various ages under the action of testosterone].

作者信息

Chernykh G V, Grigor'eva A V, Iarygin V N

出版信息

Ontogenez. 1989 Sep-Oct;20(5):500-6.

PMID:2479898
Abstract

A study of chromatin in KSTG neurocytes revealed the most remarkable changes of template activity after testosterone administration in 9 days old rats and less significant changes in adult rats. No changes were detected in 19 days old rats. The pattern of silver staining of the nuclei did not differ from the control in all age groups. The possible role of testosterone in differentiation of KSTG neurocytes in early postnatal period as well as the stage-related differences in mechanisms of the hormone action during ontogenesis are discussed.

摘要

一项对KSTG神经细胞中染色质的研究显示,在给9日龄大鼠注射睾酮后,模板活性发生了最显著的变化,而成年大鼠的变化则不太明显。在19日龄大鼠中未检测到变化。所有年龄组的细胞核银染模式与对照组无差异。文中讨论了睾酮在出生后早期KSTG神经细胞分化中的可能作用,以及在个体发育过程中激素作用机制的阶段相关差异。

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