Farooq Ayesha, Rauf Shahid, Hassan Uzma, Sadiq Naushaba
J Ayub Med Coll Abbottabad. 2011 Apr-Jun;23(2):32-5.
The effect of multiple pregnancies, a very common pattern in reproductive lifestyle of Pakistani women, needs to be addressed to see if it affects the iron content and hence cause iron deficiency. Recognising this deficiency prior to development of anaemia can prevent disastrous consequences that can complicate the life of the mother and foetus especially in developing countries. The objective of this study was to assess the effect that the stress of multiple pregnancies has on the iron status of the body.
This comparative study was conducted in a focus group of female population. Two hundred subjects were selected by convenient sampling and grouped depending on their parity status. Data regarding diet, and socioeconomic history was collected on pre-designed questionnaire. Serum Ferritin was used to assess iron deficiency using the Electrochemiluminescence Immunoassay (ECLIA). Data was statistically analysed using SPSS-17.
Mean value of serum Ferritin in the nulliparous group was 76.52 +/- 4.92 etag/mL with 16% of nulliparous subjects showing lower than normal values. Thirty-six percent of uniparous subjects showed low serum Ferritin values, mean value-being 45.74 +/- 4.51 etag/mL. Seventy-two percent of the multiparous subjects showed iron deficiency with Ferritin levels of < 20 etag/mL. Mean serum Ferritin in this group was 25.21 +/- 2.75 etag/mL. The differences between the Ferritin levels of the study groups were highly significant (p < 0.01).
Multiparous women had lower serum Ferritin levels than the control group suggesting that the stress of multiple pregnancies takes its toll on the iron content of the body.
多胎妊娠是巴基斯坦女性生殖生活中非常常见的一种模式，其影响需要加以研究，以确定它是否会影响铁含量，进而导致缺铁。在贫血发生之前识别这种缺铁情况，可以预防可能使母亲和胎儿生活复杂化的灾难性后果，尤其是在发展中国家。本研究的目的是评估多胎妊娠压力对身体铁状态的影响。
本比较研究在一组女性人群中进行。通过方便抽样选取了200名受试者，并根据其生育状况进行分组。通过预先设计的问卷收集有关饮食和社会经济史的数据。使用电化学发光免疫分析法（ECLIA）通过血清铁蛋白评估缺铁情况。使用SPSS-17对数据进行统计分析。
未生育组血清铁蛋白的平均值为76.52±4.92 etag/mL，16%的未生育受试者显示低于正常值。36%的单胎受试者血清铁蛋白值较低，平均值为45.74±4.51 etag/mL。72%的多胎受试者显示铁缺乏，铁蛋白水平<20 etag/mL。该组血清铁蛋白的平均值为25.21±2.75 etag/mL。研究组之间铁蛋白水平的差异非常显著（p<0.01）。
多胎妊娠女性的血清铁蛋白水平低于对照组，表明多胎妊娠的压力对身体的铁含量产生了影响。
