Barton James C, Barton J Clayborn, Acton Ronald T
Department of Medicine The University of Alabama at Birmingham Birmingham Alabama USA.
Southern Iron Disorders Center Birmingham Alabama USA.
EJHaem. 2025 Jul 2;6(4):e70092. doi: 10.1002/jha2.70092. eCollection 2025 Aug.
We sought to determine associations of serum ferritin (SF) with live birth numbers and other iron-related variables in women with p.C282Y (rs1800562) homozygosity.
We studied non-pregnant, non-Hispanic white women in post-screening evaluations to determine associations of SF with age, pregnancy and live birth numbers, dichotomous menopause and therapeutic phlebotomy reports, daily food and supplemental iron intakes, and transferrin saturation (TS).
There were 136 women with mean age 51 ± 13 (SD) years and median SF 238 µg/L (range: 8, 2960). There were 376 pregnancies (median: 3/woman (1, 8)) and 296 live births (median: 2/woman (0, 6)). A total of 70 women (51.5%) reported menopause and 31 women (22.8%) reported phlebotomy. Median heme + non-heme food iron intake was 13.4 mg/d (3.1, 57.3). Mean TS was 62 ± 25%. Pearson's coefficient of ln SF versus age was 0.1955 ( = 0.0226). Median SF of women with and without menopause was 386 µg/L (8, 2960) and 165 µg/L (8, 1894), respectively ( < 0.0002). SF associations with phlebotomy and iron intakes were not significant. Spearman's coefficient of SF versus TS was 0.5079 ( < 0.0001). Four mean ln SF values of 66 women without menopause subgrouped by live birth numbers were similar (one-way ANOVA = 0.4460). Multiple regressions on SF using pregnancy numbers revealed positive associations with menopause ( = 0.0157) and TS ( < 0.0001) and using live birth numbers revealed positive associations with live births ( = 0.0389), menopause ( = 0.0305), and TS ( < 0.0001).
SF levels in 136 women with p.C282Y homozygosity are positively associated with age, numbers of live births, menopause reports and TS.
我们试图确定血清铁蛋白（SF）与携带p.C282Y（rs1800562）纯合子的女性的活产数及其他铁相关变量之间的关联。
我们在筛查后评估中研究了非怀孕、非西班牙裔白人女性，以确定SF与年龄、怀孕次数和活产数、二分法绝经和治疗性放血报告、每日食物和补充铁摄入量以及转铁蛋白饱和度（TS）之间的关联。
共有136名女性，平均年龄51±13（标准差）岁，SF中位数为238μg/L（范围：8，2960）。共有376次怀孕（中位数：每位女性3次（1，8））和296次活产（中位数：每位女性2次（0，6））。共有70名女性（51.5%）报告绝经，31名女性（22.8%）报告放血。血红素+非血红素食物铁摄入量中位数为13.4mg/d（3.1，57.3）。平均TS为62±25%。SF的自然对数与年龄的Pearson系数为0.1955（P = 0.0226）。有和没有绝经的女性的SF中位数分别为386μg/L（8，2960）和165μg/L（8，1894）（P < 0.0002）。SF与放血和铁摄入量之间的关联不显著。SF与TS的Spearman系数为0.5079（P < 0.0001）。按活产数分组的66名未绝经女性的四个平均SF自然对数值相似（单因素方差分析P = 0.4460）。使用怀孕次数对SF进行多元回归显示与绝经（P = 0.0157）和TS（P < 0.0001）呈正相关，使用活产数进行多元回归显示与活产（P = 0.0389）、绝经（P = 0.0305）和TS（P < 0.0001）呈正相关。
136名携带p.C282Y纯合子的女性的SF水平与年龄、活产数、绝经报告和TS呈正相关。
