Yuan Hai-Peng, Liu Qing-Dong, Li Gai-Qin, Cong Yan-Qun
1 Department of Gastroenterology, Tai'an City Central Hospital , Tai'an, China .
Genet Test Mol Biomarkers. 2014 Jul;18(7):482-8. doi: 10.1089/gtmb.2014.0032. Epub 2014 May 6.
Tumorigenesis is a multistep process that begins with the abrogation of normal controls of apoptosis and cell proliferation, and the Fas receptor-ligand system is a key regulator of apoptosis. The Fas -670 A/G single-nucleotide polymorphism (SNP) has been demonstrated to affect the expression of the Fas gene by altering the transcriptional activity in this gene's promoter. However, the association between the Fas -670 A/G polymorphism and digestive cancer risk is still controversial and ambiguous in the Asian population, so we conducted a meta-analysis to confirm and clarify the association between the Fas -670 A/G polymorphism and digestive cancer.
A search of PubMed, China National Knowledge Infrastructure (CNKI), and WanFang databases was conducted and encompassed all available articles that had been published up to July 20, 2013. Overall, 15 case-control studies containing 3692 cases and 4895 controls were retrieved based on search criteria for digestive cancer susceptibility related to -670A/G SNP. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of this association.
In the overall analysis, the country type and source of control subgroups, no association between the Fas -670 A/G polymorphism and digestive cancer risk was found. However, in the digestive cancer-type subgroups, a significant protective effect was detected between Fas -670 A/G polymorphism and hepatocellular carcinoma in Asians (AG vs. GG: OR=0.89, 95% CI=0.80-0.99; AA+AG vs. GG: OR=0.93, 95% CI=0.87-1.00).
Our investigations demonstrated that the Fas -670 A/G polymorphism might decrease the hepatocellular carcinoma risk in Asian populations. Further studies based on larger sample sizes, other ethnicities, and gene-environment interactions should be conducted to further understand the role of Fas -670 A/G polymorphism in digestive cancer risk.
肿瘤发生是一个多步骤过程，始于对细胞凋亡和细胞增殖正常调控的废除，而Fas受体-配体系统是细胞凋亡的关键调节因子。Fas -670 A/G单核苷酸多态性（SNP）已被证明可通过改变该基因启动子中的转录活性来影响Fas基因的表达。然而，在亚洲人群中，Fas -670 A/G多态性与消化系癌症风险之间的关联仍存在争议且不明确，因此我们进行了一项荟萃分析，以确认并阐明Fas -670 A/G多态性与消化系癌症之间的关联。
检索了PubMed、中国知网（CNKI）和万方数据库，纳入截至2013年7月20日发表的所有可用文章。总体而言，根据与-670A/G SNP相关的消化系癌症易感性的检索标准，检索到15项病例对照研究，共3692例病例和4895例对照。采用比值比（OR）和95%置信区间（CI）来评估这种关联的强度。
在总体分析中，按国家类型和对照亚组来源划分，未发现Fas -670 A/G多态性与消化系癌症风险之间存在关联。然而，在消化系癌症类型亚组中，在亚洲人群中检测到Fas -670 A/G多态性与肝细胞癌之间存在显著的保护作用（AG与GG相比：OR = 0.89，95%CI = 0.80 - 0.99；AA + AG与GG相比：OR = 0.93，95%CI = 0.87 - 1.00）。
我们的研究表明，Fas -670 A/G多态性可能会降低亚洲人群患肝细胞癌的风险。应基于更大样本量、其他种族以及基因-环境相互作用开展进一步研究，以深入了解Fas -670 A/G多态性在消化系癌症风险中的作用。
