中国深圳男男性行为者中的 HPV 感染。
HPV infections among MSM in Shenzhen, China.
机构信息
Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Dermatology, Nanjing, China.
Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Dermatology, Nanjing, China; National Center for STD Control, China CDC, Nanjing, China.
出版信息
PLoS One. 2014 May 6;9(5):e96364. doi: 10.1371/journal.pone.0096364. eCollection 2014.
BACKGROUND
An increasing incidence of anal cancer among men, especially men who have sex with men (MSM) suggests a need to better understand anal human papillomavirus (HPV) infection among this group.
METHODS
A cross-sectional study was conducted among MSM in Shenzhen, China. Blood was collected for HIV serological testing and syphilis serological screening, and anal swabs were collected for HPV genotyping. Difference of HPV prevalence between HIV seropositive and HIV seronegative MSM was assessed by chi-square test. Factors associated with anal canal HPV infection were assessed by univariate and multivariate logistic regression.
RESULTS
A total of 408 MSM were recruited. HIV and HPV prevalence were 6.9% and 36.4%, respectively. HPV was detected in the anal canal in 71.4% of the HIV-positive MSM and in 33.8% of the HIV-negative MSM (P<0.001). Oncogenic types were seen more often in anal specimens of HIV-positive MSM than in specimens of HIV-negative MSM (P = 0.001). The HPV genotypes detected most frequently were HPV06 (8.2%), HPV16 (7.2%), HPV11 (6.4%), HPV18 (4.7%), HPV58 (4.7%), and HPV52 (4.2%).
CONCLUSIONS
In this study, HIV positive MSM had a higher burden of HPV infection, especially oncogenic HPV infection. HPV types 52 and 58 were as popular as those types designed for the currently available vaccine (HPV6, 11, 16, 18).
背景
男性中肛门癌的发病率不断上升，尤其是男男性行为者（MSM），这表明有必要更好地了解该人群中的肛门人乳头瘤病毒（HPV）感染。
方法
在中国深圳对 MSM 进行了横断面研究。采集血液进行 HIV 血清学检测和梅毒血清学筛查，并采集肛门拭子进行 HPV 基因分型。采用卡方检验比较 HIV 血清阳性和 HIV 血清阴性 MSM 之间 HPV 流行率的差异。采用单因素和多因素 logistic 回归评估与肛门 HPV 感染相关的因素。
结果
共招募了 408 名 MSM。HIV 和 HPV 的流行率分别为 6.9%和 36.4%。在 HIV 阳性 MSM 中，71.4%的人肛门 HPV 阳性，而在 HIV 阴性 MSM 中，33.8%的人肛门 HPV 阳性（P<0.001）。在 HIV 阳性 MSM 的肛门标本中，与 HIV 阴性 MSM 的标本相比，发现了更多的致癌型 HPV（P=0.001）。在肛门标本中检测到的最常见 HPV 基因型为 HPV06（8.2%）、HPV16（7.2%）、HPV11（6.4%）、HPV18（4.7%）、HPV58（4.7%）和 HPV52（4.2%）。
结论
在这项研究中，HIV 阳性 MSM 的 HPV 感染负担更高，尤其是致癌型 HPV 感染。HPV 类型 52 和 58 与目前可用疫苗（HPV6、11、16、18）设计的类型一样流行。
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