Ke Qiang, Zhao Ke, Jin Yujiao, Pan Xiaoyan, Ma Yanxiu, Zhang Liqin, Sun Xiaoming
School of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, Zhejiang, China.
Zhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogen Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, 311121, China.
Sci Rep. 2025 Mar 18;15(1):9374. doi: 10.1038/s41598-025-92102-9.
Oncogenic human papillomavirus (HPV) infection is a major cause of anogenital cancers in both females and males. Nevertheless, only a limited number of studies have explored the epidemiology of HPV infection across genders within the same population. This retrospective study analyzed 299,089 samples from Hangzhou, China, collected between 2017 and 2023, including 283,556 females and 15,533 males. The overall HPV infection rate was 23.8%, with a prevalence of 22.85% in females and 41.13% in males. Gender differences were observed in the prevalence of high-risk HPV. In females, the most common high-risk HPV type was HPV52 (5.58%), followed by HPV58 (2.84%) and HPV16 (2.64%). In males, HPV52 (5.28%) was also the most prevalent, followed by HPV16 (5.08%) and HPV51 (3.57%). The age-related HPV infection rate shows a bimodal pattern, peaking in individuals under 20 years old and those aged 61-65. During the COVID-19 pandemic, the overall HPV infection rate declined by approximately 3% across all age groups. This study provides valuable insights into the dynamics of HPV infection in the context of the pandemic and emphasizes the need for HPV vaccination for adolescent males.
致癌性人乳头瘤病毒（HPV）感染是女性和男性肛门生殖器癌的主要病因。然而，仅有少数研究探讨了同一人群中不同性别人群的HPV感染流行病学。这项回顾性研究分析了2017年至2023年间在中国杭州采集的299,089份样本，其中包括283,556名女性和15,533名男性。总体HPV感染率为23.8%，女性患病率为22.85%，男性患病率为41.13%。在高危HPV的患病率方面观察到了性别差异。在女性中，最常见的高危HPV类型是HPV52（5.58%），其次是HPV58（2.84%）和HPV16（2.64%）。在男性中，HPV52（5.28%）也是最普遍的，其次是HPV16（5.08%）和HPV51（3.57%）。与年龄相关的HPV感染率呈双峰模式，在20岁以下个体和61 - 65岁个体中达到峰值。在新冠疫情期间，所有年龄组的总体HPV感染率下降了约3%。这项研究为疫情背景下HPV感染的动态变化提供了有价值的见解，并强调了青少年男性接种HPV疫苗的必要性。
