Poly(ADP-ribose) polymerase activity is inhibited by 2',5'-oligoadenylates in mouse L-cells.
作者信息
Buonamassa D T, Malanga M, Coccia E M, Romeo G, Affabris E, Farina B, Suzuki H
机构信息
Centro Richerche Sclavo, Siena, Italy.
出版信息
FEBS Lett. 1989 Nov 20;258(1):163-5. doi: 10.1016/0014-5793(89)81641-2.
PMID:2480249
Abstract
Down regulation of poly(ADP-ribose)polymerase (ADPRP) activity was observed in mouse LW-cells after treatment with 2'-5'oligoadenylates or with fibroblast interferon and poly(rI) poly(rC). The poly(rI) poly(rC)-induced inhibition of the enzymatic activity correlates with the observed increase of endogenous 2',5'-oligoadenylate cores which were reported to be potent inhibitors of ADPRP in vitro.
摘要
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