Floyd-Smith G, Slattery E, Lengyel P
Science. 1981 May 29;212(4498):1030-2. doi: 10.1126/science.6165080.
One of the mediators of interferon action is a latent endoribonuclease (ribonuclease L) that is activated by (2'-5')oligoadenylates. Among the homopolymers of the four common ribonucleotides, activated ribonuclease L degrades at an appreciable rate only polyuridylic acid. In two natural RNA's tested the most frequent ribonuclease L cleavages occur after UA, UG, and UU (A, adenine; U, uracil; and G, guanine) and much less frequent cleavages after CA and AC (C, cytosine).
干扰素作用的介质之一是一种潜在的核糖核酸内切酶（核糖核酸酶L），它被（2'-5'）寡聚腺苷酸激活。在四种常见核糖核苷酸的均聚物中，活化的核糖核酸酶L仅以可观的速率降解聚尿苷酸。在所测试的两种天然RNA中，核糖核酸酶L最常见的切割发生在UA、UG和UU之后（A，腺嘌呤；U，尿嘧啶；G，鸟嘌呤），而在CA和AC之后的切割则少得多（C，胞嘧啶）。
