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基于层状氢氧化物的药物传递系统在纳米医学中的发展。

Development of drug delivery systems based on layered hydroxides for nanomedicine.

机构信息

Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, UPM, Serdang 43400, Malaysia.

Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, UPM, Serdang 43400, Malaysia.

出版信息

Int J Mol Sci. 2014 May 5;15(5):7750-86. doi: 10.3390/ijms15057750.

Abstract

Layered hydroxides (LHs) have recently fascinated researchers due to their wide application in various fields. These inorganic nanoparticles, with excellent features as nanocarriers in drug delivery systems, have the potential to play an important role in healthcare. Owing to their outstanding ion-exchange capacity, many organic pharmaceutical drugs have been intercalated into the interlayer galleries of LHs and, consequently, novel nanodrugs or smart drugs may revolutionize in the treatment of diseases. Layered hydroxides, as green nanoreservoirs with sustained drug release and cell targeting properties hold great promise of improving health and prolonging life.

摘要

层状氢氧化物 (Layered hydroxides, LHs) 因其在各个领域的广泛应用而引起了研究人员的极大关注。这些无机纳米粒子作为药物传递系统中的纳米载体具有优异的特性,有望在医疗保健领域发挥重要作用。由于其出色的离子交换能力,许多有机药物已被插入 LHs 的层间腔室中,因此新型纳米药物或智能药物可能会彻底改变疾病的治疗方法。层状氢氧化物作为具有持续药物释放和细胞靶向特性的绿色纳米储库,有望改善健康状况并延长寿命。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0f2/4057703/ad5cef7e4c68/ijms-15-07750f1.jpg

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