抗生素两性霉素B（制霉菌素）对小鼠骨髓瘤细胞系和丝裂原刺激的B淋巴细胞增殖的抑制作用。
Inhibition of proliferation of a murine myeloma cell line and mitogen-stimulated B lymphocytes by the antibiotic amphotericin B (Fungizone).
作者信息
Walls E V, Kay J E
出版信息
Immunology. 1982 Sep;47(1):115-21.
Abstract
Amphotericin B at the concentration normally used for routine suppression of fungal infection in tissue culture strongly inhibits the proliferation of NS1/1 myeloma cells and the LPS-induced activation of B lymphocytes from mouse spleen. The proliferation of T lymphocytes induced by concanavalin A (Con A) was less affected by the antibiotic, indicating that B-lymphocyte proliferation was preferentially inhibited. The unexpected sensitivity of B-lymphoid cells to amphotericin B precludes its use as an anti-fungal agent in the production of hybridomas from fusions between these cells.
摘要
两性霉素B在组织培养中用于常规抑制真菌感染的正常浓度下，能强烈抑制NS1/1骨髓瘤细胞的增殖以及脂多糖诱导的小鼠脾脏B淋巴细胞的活化。伴刀豆球蛋白A（Con A）诱导的T淋巴细胞增殖受该抗生素的影响较小，这表明B淋巴细胞增殖受到了优先抑制。B淋巴细胞对两性霉素B出人意料的敏感性使其无法在这些细胞融合产生杂交瘤的过程中用作抗真菌剂。
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