Korbel Lindsey, George Mathew, Kitzmiller Joseph
The Ohio State University College of Medicine, Columbus, OH, USA
St Barnabas Hospital, Bronx, NY, USA.
Clin Pediatr (Phila). 2014 Aug;53(9):831-8. doi: 10.1177/0009922814533186. Epub 2014 May 6.
Clinicians and patients continue to convey interest in personalized medicine. The objective of personalized medicine is to improve healthcare by tailoring disease prevention, diagnosis, and treatment strategies for individuals based on their unique clinical history and genetic composition. This article offers an overview of pharmacogenomics, discusses caveats specific to pharmacogenomics in pediatric populations, provides evidence-based recommendations for pediatric clinicians, and offers insight regarding the future role of pharmacogenomics testing in pediatric medicine. Reviews of the current literature and thoughtful discussions are presented regarding the pharmacogenomics of antidepressants, codeine and oncologic, asthma, and immunomodulatory pharmacotherapies.
临床医生和患者对个性化医疗的兴趣持续不减。个性化医疗的目标是根据个体独特的临床病史和基因组成，量身定制疾病预防、诊断和治疗策略，从而改善医疗保健。本文概述了药物基因组学，讨论了儿科人群中药物基因组学的特殊注意事项，为儿科临床医生提供循证建议，并深入探讨了药物基因组学检测在儿科医学中的未来作用。针对抗抑郁药、可待因、肿瘤学、哮喘和免疫调节药物疗法的药物基因组学，对当前文献进行了综述并展开了深入讨论。
