Stamp G W
ICRF/RCS Histopathology Unit, London, U.K.
J Pathol. 1989 Nov;159(3):225-9. doi: 10.1002/path.1711590309.
The distribution of tenascin, an extracellular matrix protein highly expressed in the stroma around sites of epithelial-mesenchymal interaction during morphogenesis and in malignant neoplasms, was assessed in cryostat sections of 17 basal cell carcinomas using a polyclonal antibody. There was marked staining of the vascularized stroma around neoplastic islands, usually as an intense, well-defined band, but being more widespread and diffuse in sclerosing, infiltrative areas. Apparently enhanced staining was seen in tumours showing retraction artefact, which may be related to the observation that tenascin interferes with the cell binding function of fibronectin. Reduced staining was seen in areas showing evidence of tumour regression. Tenascin is an important component of the epithelial-mesenchymal interactive process and further studies on its distribution in benign and malignant skin tumours are required.
用一种多克隆抗体对17例基底细胞癌的冰冻切片进行检测，评估腱生蛋白（一种细胞外基质蛋白，在形态发生过程中上皮-间充质相互作用部位周围的基质以及恶性肿瘤中高度表达）的分布情况。肿瘤岛周围的血管化基质有明显染色，通常呈强烈、界限清晰的条带，但在硬化性浸润区域更广泛、更弥散。在显示退缩假象的肿瘤中可见明显增强的染色，这可能与腱生蛋白干扰纤连蛋白的细胞结合功能这一观察结果有关。在显示肿瘤消退迹象的区域可见染色减弱。腱生蛋白是上皮-间充质相互作用过程的重要组成部分，需要进一步研究其在良性和恶性皮肤肿瘤中的分布情况。
