J Biomed Nanotechnol. 2014 Jul;10(7):1267-76. doi: 10.1166/jbn.2014.1838.
Nanomaterial-directed, photothermal ablation is a practical future approach for the treatment of early-stage bladder cancer. Using a new PEGylation technique with bi-functional nitrophenyl carbonate PEG (bi-NPC-PEG) that promotes uniform suspension of the nanomaterial in solution, we have shown that gold nanorods conjugated to an anti-EGFR antibody (nano-alphaEGFR) bind effectively to EGFR-expressing bladder cancer cells. The subsequent application of infrared light, specifically tuned to the plasmon resonance of the nanorods used in this work, allows for the specific heating of nano-alphaEGFR to the point of localized cellular death. Such an approach, administering nano-alphaEGFR intravesically via a urinary catheter and infrared light via a modified cystoscope, represents a novel, future clinical application of this technology, which avoids the problem of systemic exposure and clearance of nanoparticles from body.
纳米材料导向的光热消融是治疗早期膀胱癌的一种有前途的方法。我们使用一种新的聚乙二醇化技术，即具有双官能硝基碳酸酯聚乙二醇（bi-NPC-PEG），促进纳米材料在溶液中的均匀悬浮，已经表明与抗 EGFR 抗体偶联的金纳米棒（nano-alphaEGFR）可以有效地与 EGFR 表达的膀胱癌细胞结合。随后应用特定于本工作中使用的纳米棒等离子体共振的红外光，可以将 nano-alphaEGFR 特异性加热到局部细胞死亡的程度。这种方法通过导尿管向膀胱内给予 nano-alphaEGFR，通过改良的膀胱镜给予红外光，代表了该技术的一种新颖的未来临床应用，避免了纳米颗粒从体内全身暴露和清除的问题。
