Wallace Deanna L, Aarts Esther, Dang Linh C, Greer Stephanie M, Jagust William J, D'Esposito Mark
Helen Wills Neuroscience Institute, University of California, Berkeley, California, United States of America.
Helen Wills Neuroscience Institute, University of California, Berkeley, California, United States of America; Center for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
PLoS One. 2014 May 7;9(5):e96319. doi: 10.1371/journal.pone.0096319. eCollection 2014.
To date, few studies have explored the neurochemical mechanisms supporting individual differences in food preference in humans. Here we investigate how dorsal striatal dopamine, as measured by the positron emission tomography (PET) tracer [(18)F]fluorometatyrosine (FMT), correlates with food-related decision-making, as well as body mass index (BMI) in 16 healthy-weight to moderately obese individuals. We find that lower PET FMT dopamine synthesis binding potential correlates with higher BMI, greater preference for perceived "healthy" foods, but also greater healthiness ratings for food items. These findings further substantiate the role of dorsal striatal dopamine in food-related behaviors and shed light on the complexity of individual differences in food preference.
迄今为止，很少有研究探讨支持人类食物偏好个体差异的神经化学机制。在此，我们研究了通过正电子发射断层扫描（PET）示踪剂[（18）F]氟代间酪氨酸（FMT）测量的背侧纹状体多巴胺如何与食物相关决策以及16名健康体重至中度肥胖个体的体重指数（BMI）相关。我们发现，较低的PET FMT多巴胺合成结合潜能与较高的BMI、对“健康”食物的更高偏好以及食物的更高健康评分相关。这些发现进一步证实了背侧纹状体多巴胺在食物相关行为中的作用，并揭示了食物偏好个体差异的复杂性。
