• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

肥胖与大脑:成瘾模型有多大说服力?

Obesity and the brain: how convincing is the addiction model?

机构信息

Department of Psychiatry, University of Cambridge, Herchel Smith Building, Addenbrooke's Hospital, Cambridge CB2 0SZ, UK.

出版信息

Nat Rev Neurosci. 2012 Mar 14;13(4):279-86. doi: 10.1038/nrn3212.

DOI:10.1038/nrn3212
PMID:22414944
Abstract

An increasingly influential perspective conceptualizes both obesity and overeating as a food addiction accompanied by corresponding brain changes. Because there are far-reaching implications for clinical practice and social policy if it becomes widely accepted, a critical evaluation of this model is important. We examine the current evidence for the link between addiction and obesity, identifying several fundamental shortcomings in the model, as well as weaknesses and inconsistencies in the empirical support for it from human neuroscientific research.

摘要

一种日益有影响力的观点将肥胖和暴食视为一种伴随着相应大脑变化的食物成瘾。因为如果这一观点被广泛接受,那么它对临床实践和社会政策都有着深远的影响,所以对这一模型进行批判性评估是很重要的。我们考察了成瘾与肥胖之间联系的现有证据,确定了该模型存在几个根本性的缺陷,以及从人类神经科学研究中对其提供的实证支持的弱点和不一致性。

相似文献

1
Obesity and the brain: how convincing is the addiction model?肥胖与大脑:成瘾模型有多大说服力?
Nat Rev Neurosci. 2012 Mar 14;13(4):279-86. doi: 10.1038/nrn3212.
2
Obesity and its relationship to addictions: is overeating a form of addictive behavior?肥胖及其与成瘾的关系:暴饮暴食是一种成瘾行为吗?
Am J Addict. 2009 Nov-Dec;18(6):439-51. doi: 10.3109/10550490903205579.
3
Food addiction and body-mass-index: a non-linear relationship.食物成瘾与身体质量指数:非线性关系。
Med Hypotheses. 2012 Oct;79(4):508-11. doi: 10.1016/j.mehy.2012.07.005. Epub 2012 Jul 31.
4
Food reward, hyperphagia, and obesity.食物奖励、暴食和肥胖。
Am J Physiol Regul Integr Comp Physiol. 2011 Jun;300(6):R1266-77. doi: 10.1152/ajpregu.00028.2011. Epub 2011 Mar 16.
5
Tossing the baby out with the bathwater after a brief rinse? The potential downside of dismissing food addiction based on limited data.匆匆冲洗一下就把婴儿和洗澡水一起倒掉?基于有限数据而摒弃食物成瘾这一概念的潜在弊端。
Nat Rev Neurosci. 2012 Jun 20;13(7):514; author reply 514. doi: 10.1038/nrn3212-c1.
6
Stress as a common risk factor for obesity and addiction.压力作为肥胖和成瘾的常见风险因素。
Biol Psychiatry. 2013 May 1;73(9):827-35. doi: 10.1016/j.biopsych.2013.01.032. Epub 2013 Mar 26.
7
Roles of "Wanting" and "Liking" in Motivating Behavior: Gambling, Food, and Drug Addictions.“想要”与“喜欢”在激发行为中的作用:赌博、食物及药物成瘾
Curr Top Behav Neurosci. 2016;27:105-36. doi: 10.1007/7854_2015_387.
8
Obesity, food, and addiction: emerging neuroscience and clinical and public health implications.肥胖、食物与成瘾:新兴神经科学以及对临床和公共卫生的影响
Neuropsychopharmacology. 2014 Jan;39(1):249-50. doi: 10.1038/npp.2013.198.
9
The Neurobiology of "Food Addiction" and Its Implications for Obesity Treatment and Policy.“食物成瘾”的神经生物学及其对肥胖治疗和政策的启示。
Annu Rev Nutr. 2016 Jul 17;36:105-28. doi: 10.1146/annurev-nutr-071715-050909. Epub 2016 Jun 1.
10
Overlaps in the nosology of substance abuse and overeating: the translational implications of "food addiction".物质滥用与暴饮暴食分类学中的重叠:“食物成瘾”的转化意义。
Curr Drug Abuse Rev. 2011 Sep;4(3):133-9. doi: 10.2174/1874473711104030133.

引用本文的文献

1
The battle over "food addiction".关于“食物成瘾”的争论
Front Psychiatry. 2025 Aug 28;16:1621742. doi: 10.3389/fpsyt.2025.1621742. eCollection 2025.
2
A personalized approach to understanding food cravings and intake: a study protocol.一种理解食物渴望与摄入量的个性化方法:一项研究方案。
J Eat Disord. 2025 Jun 4;13(1):103. doi: 10.1186/s40337-025-01303-0.
3
GABA Receptor: Structure, Biological Functions, and Therapy for Diseases.γ-氨基丁酸受体:结构、生物学功能及疾病治疗

本文引用的文献

1
Neurocognitive endophenotypes of impulsivity and compulsivity: towards dimensional psychiatry.冲动和强迫的神经认知内表型:走向维度精神病学。
Trends Cogn Sci. 2012 Jan;16(1):81-91. doi: 10.1016/j.tics.2011.11.009. Epub 2011 Dec 10.
2
Common cellular and molecular mechanisms in obesity and drug addiction.肥胖症和药物成瘾的常见细胞和分子机制。
Nat Rev Neurosci. 2011 Oct 20;12(11):638-51. doi: 10.1038/nrn3105.
3
Reward abnormalities among women with full and subthreshold bulimia nervosa: a functional magnetic resonance imaging study.
MedComm (2020). 2025 Apr 16;6(5):e70163. doi: 10.1002/mco2.70163. eCollection 2025 May.
4
Comparison of Attachment Styles of Individuals with Opioid Use Disorder and Individuals with Obesity.患有阿片类物质使用障碍的个体与肥胖个体的依恋风格比较。
Turk Psikiyatri Derg. 2024 Sep 19;36:47-55. doi: 10.5080/u27003.
5
Current perspectives on brain circuits involved in food addiction-like behaviors.当前对涉及食物成瘾样行为的大脑回路的观点。
J Neural Transm (Vienna). 2024 May;131(5):475-485. doi: 10.1007/s00702-023-02732-4. Epub 2024 Jan 12.
6
Linking drug and food addiction: an overview of the shared neural circuits and behavioral phenotype.连接药物成瘾与食物成瘾:共享神经回路与行为表型概述
Front Behav Neurosci. 2023 Sep 12;17:1240748. doi: 10.3389/fnbeh.2023.1240748. eCollection 2023.
7
Understanding the Impact of Social Networks on the Spread of Obesity.理解社交网络对肥胖传播的影响。
Int J Environ Res Public Health. 2023 Jul 26;20(15):6451. doi: 10.3390/ijerph20156451.
8
Food addiction and its relationship with other eating behaviours among Spanish university students.西班牙大学生中的食物成瘾及其与其他饮食行为的关系。
J Eat Disord. 2023 Apr 12;11(1):60. doi: 10.1186/s40337-023-00772-5.
9
Maternal Over- and Malnutrition and Increased Risk for Addictive and Eating Disorders in the Offspring.母体营养过剩和营养不良与后代成瘾和饮食失调风险增加。
Nutrients. 2023 Feb 22;15(5):1095. doi: 10.3390/nu15051095.
10
Disordered Eating Behaviors Related to Food Addiction/Eating Addiction in Inpatients with Obesity and the General Population: The Italian Version of the Addiction-like Eating Behaviors Scale (AEBS-IT).肥胖住院患者和一般人群中与食物成瘾/饮食成瘾相关的饮食失调行为:类似成瘾的饮食行为量表(AEBS-IT)的义大利文版本。
Nutrients. 2022 Dec 25;15(1):104. doi: 10.3390/nu15010104.
奖励完全和阈下神经性贪食症女性中的异常:一项功能磁共振成像研究。
Int J Eat Disord. 2011 Nov;44(7):585-95. doi: 10.1002/eat.20869. Epub 2010 Nov 5.
4
Addiction circuitry in the human brain.人类大脑中的成瘾回路。
Annu Rev Pharmacol Toxicol. 2012;52:321-36. doi: 10.1146/annurev-pharmtox-010611-134625. Epub 2011 Sep 27.
5
Evidence that 'food addiction' is a valid phenotype of obesity.有证据表明,“食物成瘾”是肥胖的一种有效表型。
Appetite. 2011 Dec;57(3):711-7. doi: 10.1016/j.appet.2011.08.017. Epub 2011 Sep 3.
6
Quantification of the effect of energy imbalance on bodyweight.能量失衡对体重影响的量化。
Lancet. 2011 Aug 27;378(9793):826-37. doi: 10.1016/S0140-6736(11)60812-X.
7
The global obesity pandemic: shaped by global drivers and local environments.全球肥胖症大流行:由全球驱动因素和本地环境共同塑造。
Lancet. 2011 Aug 27;378(9793):804-14. doi: 10.1016/S0140-6736(11)60813-1.
8
Differential neural responses to food images in women with bulimia versus anorexia nervosa.贪食症与厌食症女性对食物图像的差异神经反应。
PLoS One. 2011;6(7):e22259. doi: 10.1371/journal.pone.0022259. Epub 2011 Jul 20.
9
Food addiction: an examination of the diagnostic criteria for dependence.食物成瘾:对依赖诊断标准的考察。
J Addict Med. 2009 Mar;3(1):1-7. doi: 10.1097/ADM.0b013e318193c993.
10
Altered temporal difference learning in bulimia nervosa.神经性贪食症中的时间差异学习改变。
Biol Psychiatry. 2011 Oct 15;70(8):728-735. doi: 10.1016/j.biopsych.2011.05.011. Epub 2011 Jun 29.