正电子发射断层扫描成像预测未来体重和可卡因偏好。
PET imaging predicts future body weight and cocaine preference.
机构信息
Behavioral Neuropharmacology Lab, Medical Department, Building 490, Brookhaven National Laboratory, Upton, NY 11973, USA.
出版信息
Neuroimage. 2012 Jan 16;59(2):1508-13. doi: 10.1016/j.neuroimage.2011.08.028. Epub 2011 Aug 26.
Abstract
Deficits in dopamine D2/D3 receptor (D2R/D3R) binding availability using PET imaging have been reported in obese humans and rodents. Similar deficits have been reported in cocaine-addicts and cocaine-exposed primates. We found that D2R/D3R binding availability negatively correlated with measures of body weight at the time of scan (ventral striatum), at 1 (ventral striatum) and 2 months (dorsal and ventral striatum) post scan in rats. Cocaine preference was negatively correlated with D2R/D3R binding availability 2 months (ventral striatum) post scan. Our findings suggest that inherent deficits in striatal D2R/D3R signaling are related to obesity and drug addiction susceptibility and that ventral and dorsal striatum serve dissociable roles in maintaining weight gain and cocaine preference. Measuring D2R/D3R binding availability provides a way for assessing susceptibility to weight gain and cocaine abuse in rodents and given the translational nature of PET imaging, potentially primates and humans.
摘要
使用正电子发射断层扫描（PET）成像技术已经在肥胖的人类和啮齿动物中发现了多巴胺 D2/D3 受体（D2R/D3R）结合可用性的缺陷。在可卡因成瘾者和可卡因暴露的灵长类动物中也报告了类似的缺陷。我们发现，D2R/D3R 结合可用性与扫描时的体重测量值（腹侧纹状体）以及扫描后 1 个月（腹侧纹状体）和 2 个月（背侧和腹侧纹状体）呈负相关。可卡因偏好与扫描后 2 个月（腹侧纹状体）的 D2R/D3R 结合可用性呈负相关。我们的研究结果表明，纹状体 D2R/D3R 信号的固有缺陷与肥胖和药物成瘾易感性有关，腹侧和背侧纹状体在维持体重增加和可卡因偏好方面起着不同的作用。测量 D2R/D3R 结合可用性为评估啮齿动物对体重增加和可卡因滥用的易感性提供了一种方法，鉴于 PET 成像的转化性质，可能还包括灵长类动物和人类。
相似文献
1
PET imaging predicts future body weight and cocaine preference.正电子发射断层扫描成像预测未来体重和可卡因偏好。
Neuroimage. 2012 Jan 16;59(2):1508-13. doi: 10.1016/j.neuroimage.2011.08.028. Epub 2011 Aug 26.
2
Opposing relationships of BMI with BOLD and dopamine D2/3 receptor binding potential in the dorsal striatum.体重指数（BMI）与背侧纹状体中血氧水平依赖性功能磁共振成像（BOLD）及多巴胺D2/3受体结合潜能之间的相反关系。
Synapse. 2015 Apr;69(4):195-202. doi: 10.1002/syn.21809. Epub 2015 Mar 11.
3
PET imaging of dopamine transporters and D2/D3 receptors in female monkeys: effects of chronic cocaine self-administration.正电子发射断层扫描（PET）成像示踪多巴胺转运体和 D2/D3 受体在雌性猴子中的变化：慢性可卡因自身给药的影响。
Neuropsychopharmacology. 2023 Sep;48(10):1436-1445. doi: 10.1038/s41386-023-01622-3. Epub 2023 Jun 22.
4
Socioeconomic status is associated with striatal dopamine D2/D3 receptors in healthy volunteers but not in cocaine abusers.社会经济地位与健康志愿者纹状体多巴胺D2/D3受体有关，但与可卡因滥用者无关。
Neurosci Lett. 2016 Mar 23;617:27-31. doi: 10.1016/j.neulet.2016.01.056. Epub 2016 Jan 29.
5
Regional and source-based patterns of [C]-(+)-PHNO binding potential reveal concurrent alterations in dopamine D and D receptor availability in cocaine-use disorder.基于区域和来源的[C]-(+)-PHNO结合潜能模式揭示了可卡因使用障碍中多巴胺D1和D2受体可用性的同时改变。
Neuroimage. 2017 Mar 1;148:343-351. doi: 10.1016/j.neuroimage.2017.01.045. Epub 2017 Jan 19.
6
Effects of chronic oral methylphenidate on cocaine self-administration and striatal dopamine D2 receptors in rodents.慢性口服哌醋甲酯对啮齿动物可卡因自我给药及纹状体多巴胺D2受体的影响。
Pharmacol Biochem Behav. 2007 Oct;87(4):426-33. doi: 10.1016/j.pbb.2007.05.020. Epub 2007 Jun 5.
7
Lack of age-dependent decrease in dopamine D3 receptor availability: a [(11)C]-(+)-PHNO and [(11)C]-raclopride positron emission tomography study.多巴胺D3受体可用性缺乏年龄依赖性降低：一项[(11)C]-(+)-PHNO和[(11)C]-雷氯必利正电子发射断层扫描研究。
J Cereb Blood Flow Metab. 2015 Nov;35(11):1812-8. doi: 10.1038/jcbfm.2015.129. Epub 2015 Jun 10.
8
Prediction of striatal D2 receptor binding by DRD2/ANKK1 TaqIA allele status.通过DRD2/ANKK1 TaqIA等位基因状态预测纹状体D2受体结合情况。
Synapse. 2016 Oct;70(10):418-31. doi: 10.1002/syn.21916. Epub 2016 Jun 17.
9
Cue-induced dopamine release predicts cocaine preference: positron emission tomography studies in freely moving rodents.线索诱导的多巴胺释放可预测可卡因偏好：对自由活动啮齿动物的正电子发射断层扫描研究
J Neurosci. 2009 May 13;29(19):6176-85. doi: 10.1523/JNEUROSCI.5221-08.2009.
10
Dopamine D3 receptor binding of (18)F-fallypride: Evaluation using in vitro and in vivo PET imaging studies.（18）F-法螺必利的多巴胺D3受体结合：使用体外和体内PET成像研究进行评估。
Synapse. 2015 Dec;69(12):577-91. doi: 10.1002/syn.21867. Epub 2015 Oct 15.
引用本文的文献
1
Striatal astrocytes modulate behavioral flexibility and whole-body metabolism in mice.纹状体星形胶质细胞调节小鼠的行为灵活性和全身代谢。
Nat Commun. 2025 Jul 7;16(1):5417. doi: 10.1038/s41467-025-60968-y.
2
Cocaine self-administration attenuates brain glucose metabolism and functional connectivity in rats.可卡因自身给药可减弱大鼠大脑葡萄糖代谢及功能连接。
PLoS One. 2025 Jun 6;20(6):e0324522. doi: 10.1371/journal.pone.0324522. eCollection 2025.
3
Association of dopamine D2-like and D receptor function with initial sensitivity to cocaine reinforcement in male rhesus monkeys.多巴胺 D2 样和 D 受体功能与雄性恒河猴对可卡因强化作用的初始敏感性相关。
Brain Res. 2023 May 15;1807:148323. doi: 10.1016/j.brainres.2023.148323. Epub 2023 Mar 11.
4
Dopamine D2 receptors bidirectionally regulate striatal enkephalin expression: Implications for cocaine reward.多巴胺 D2 受体双向调节纹状体脑啡肽表达：可卡因奖赏的意义。
Cell Rep. 2022 Sep 27;40(13):111440. doi: 10.1016/j.celrep.2022.111440.
5
Prenatal Effects of Nicotine on Obesity Risks: A Narrative Review.孕期尼古丁暴露对肥胖风险的影响：一项叙述性综述。
Int J Environ Res Public Health. 2022 Aug 2;19(15):9477. doi: 10.3390/ijerph19159477.
6
The functional networks of a novel environment: Neural activity mapping in awake unrestrained rats using positron emission tomography.在清醒自由活动的大鼠中使用正电子发射断层扫描对新环境的功能网络进行神经活动映射。
Brain Behav. 2020 Aug;10(8):e01646. doi: 10.1002/brb3.1646. Epub 2020 Jun 20.
7
New insights into weight management by orlistat in comparison with cinnamon as a natural lipase inhibitor.与作为天然脂肪酶抑制剂的肉桂相比，奥利司他在体重管理方面的新见解。
Endocrine. 2020 Jan;67(1):109-116. doi: 10.1007/s12020-019-02127-0. Epub 2019 Nov 13.
8
Pituitary Gland Functional Connectivity and BMI.垂体功能连接与体重指数
Front Neurosci. 2019 Mar 1;13:120. doi: 10.3389/fnins.2019.00120. eCollection 2019.
9
D1 receptor hypersensitivity in mice with low striatal D2 receptors facilitates select cocaine behaviors.低纹状体 D2 受体的小鼠 D1 受体超敏可促进特定可卡因行为。
Neuropsychopharmacology. 2019 Mar;44(4):805-816. doi: 10.1038/s41386-018-0286-3. Epub 2018 Dec 1.
10
Sugar Addiction: From Evolution to Revolution.糖成瘾：从进化到变革
Front Psychiatry. 2018 Nov 7;9:545. doi: 10.3389/fpsyt.2018.00545. eCollection 2018.
本文引用的文献
1
Weight gain is associated with reduced striatal response to palatable food.体重增加与对美味食物的纹状体反应减少有关。
J Neurosci. 2010 Sep 29;30(39):13105-9. doi: 10.1523/JNEUROSCI.2105-10.2010.
2
Variability in brain activity as an individual difference measure in neuroscience?作为神经科学中个体差异测量指标的大脑活动变异性？
J Neurosci. 2010 Jun 9;30(23):7755-7. doi: 10.1523/JNEUROSCI.1560-10.2010.
3
Cue-induced dopamine release predicts cocaine preference: positron emission tomography studies in freely moving rodents.线索诱导的多巴胺释放可预测可卡因偏好：对自由活动啮齿动物的正电子发射断层扫描研究
J Neurosci. 2009 May 13;29(19):6176-85. doi: 10.1523/JNEUROSCI.5221-08.2009.
4
Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors.条件性位置偏爱和运动活动对缺乏多巴胺 D4 受体的小鼠中哌醋甲酯、安非他命和可卡因的反应。
J Psychopharmacol. 2010 Jun;24(6):897-904. doi: 10.1177/0269881109102613. Epub 2009 Mar 12.
5
Dorsal striatal-midbrain connectivity in humans predicts how reinforcements are used to guide decisions.人类背侧纹状体与中脑的连接性可预测强化如何用于指导决策。
J Cogn Neurosci. 2009 Jul;21(7):1332-45. doi: 10.1162/jocn.2009.21092.
6
Review. Positron emission tomography imaging studies of dopamine receptors in primate models of addiction.综述：成瘾灵长类动物模型中多巴胺受体的正电子发射断层扫描成像研究
Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12;363(1507):3223-32. doi: 10.1098/rstb.2008.0092.
7
High impulsivity predicts the switch to compulsive cocaine-taking.高冲动性预示着会转变为强迫性可卡因吸食。
Science. 2008 Jun 6;320(5881):1352-5. doi: 10.1126/science.1158136.
8
Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in-vivo muPET imaging ([11C] raclopride) and in-vitro ([3H] spiperone) autoradiography.在肥胖大鼠模型中，通过体内μPET成像（[11C]雷氯必利）和体外（[3H]螺哌隆）放射自显影评估发现，食物限制显著增加多巴胺D2受体（D2R）。
Synapse. 2008 Jan;62(1):50-61. doi: 10.1002/syn.20468.
9
Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement.伏隔核D2/3受体可预测特质冲动性和可卡因强化作用。
Science. 2007 Mar 2;315(5816):1267-70. doi: 10.1126/science.1137073.
10
Similarity between obesity and drug addiction as assessed by neurofunctional imaging: a concept review.通过神经功能成像评估肥胖与药物成瘾之间的相似性：概念综述
J Addict Dis. 2004;23(3):39-53. doi: 10.1300/J069v23n03_04.
Zotero 插件