国际空间站二氧化碳水平与报告头痛之间的关系。
Relationship between carbon dioxide levels and reported headaches on the international space station.
机构信息
From the NASA Johnson Space Center (Dr Law, Ms Van Baalen, Dr Meyers, and Dr Alexander), Wyle Science, Technology and Engineering (Drs Foy and Wear), and MEI Technologies (Mrs Mason and Ms Mendez), Houston, Tex.
出版信息
J Occup Environ Med. 2014 May;56(5):477-83. doi: 10.1097/JOM.0000000000000158.
OBJECTIVE
Because of anecdotal reports of CO(2)-related symptoms onboard the International Space Station (ISS), the relationship between CO(2) and in-flight headaches was analyzed.
METHODS
Headache reports and CO(2) measurements were obtained, and arithmetic means and single-point maxima were determined for 24-hour and 7-day periods. Multiple imputation addressed missing data, and logistic regression modeled the relationship between CO(2), headache probability, and covariates.
RESULTS
CO(2) level, age at launch, time in-flight, and data source were significantly associated with headache. For each 1-mm Hg increase in CO(2), the odds of a crew member reporting a headache doubled. To keep the risk of headache below 1%, average 7-day CO(2) would need to be maintained below 2.5 mm Hg (current ISS range: 1 to 9 mm Hg).
CONCLUSIONS
Although headache incidence was not high, results suggest an increased susceptibility to physiological effects of CO(2) in-flight.
目的
由于国际空间站（ISS）上有关于 CO(2)相关症状的传闻报告，因此分析了 CO(2)与飞行性头痛之间的关系。
方法
获取头痛报告和 CO(2)测量值，并确定 24 小时和 7 天周期的算术平均值和单点最大值。多重插补法处理缺失数据，逻辑回归模型则用于分析 CO(2)、头痛概率和协变量之间的关系。
结果
CO(2)水平、发射时的年龄、飞行时间和数据来源与头痛显著相关。CO(2)每增加 1mmHg，机组人员报告头痛的几率就会增加一倍。要将头痛风险保持在 1%以下，则需要将平均 7 天 CO(2)保持在 2.5mmHg 以下（当前 ISS 范围为 1 至 9mmHg）。
结论
尽管头痛发生率不高，但结果表明，在飞行过程中对 CO(2)生理影响的敏感性增加。
Zotero 插件