一项关于调控细胞收缩性的应力纤维-黏着斑动力学的计算研究。
A computational study of stress fiber-focal adhesion dynamics governing cell contractility.
作者信息
Maraldi M, Valero C, Garikipati K
机构信息
Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan.
Aragón Institute of Engineering Research, University of Zaragoza, Zaragoza, Spain.
出版信息
Biophys J. 2014 May 6;106(9):1890-901. doi: 10.1016/j.bpj.2014.03.027.
We apply a recently developed model of cytoskeletal force generation to study a cell's intrinsic contractility, as well as its response to external loading. The model is based on a nonequilibrium thermodynamic treatment of the mechanochemistry governing force in the stress fiber-focal adhesion system. Our computational study suggests that the mechanical coupling between the stress fibers and focal adhesions leads to a complex, dynamic, mechanochemical response. We collect the results in response maps whose regimes are distinguished by the initial geometry of the stress fiber-focal adhesion system, and by the external load on the cell. The results from our model connect qualitatively with recent studies on the force response of smooth muscle cells on arrays of polymeric microposts.
我们应用一种最近开发的细胞骨架力产生模型来研究细胞的内在收缩性及其对外部加载的反应。该模型基于对应力纤维 - 粘着斑系统中力的机械化学进行的非平衡热力学处理。我们的计算研究表明，应力纤维和粘着斑之间的机械耦合会导致复杂、动态的机械化学反应。我们将结果收集在响应图中，这些响应图的区域由应力纤维 - 粘着斑系统的初始几何形状以及细胞上的外部负载来区分。我们模型的结果与最近关于平滑肌细胞在聚合物微柱阵列上的力响应的研究在定性上相关。
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