Katoh Kazuo, Kano Yumiko, Ookawara Shigeo
Department of Anatomy, School, of Medicine, Jichi Medical University, Yakushiji, Shimotsuke-city, Tochigi, Japan.
Vasc Health Risk Manag. 2008;4(6):1273-82. doi: 10.2147/vhrm.s3933.
Fluid shear stress is the mechanical force generated by the blood flow which is applied over the apical surface of endothelial cells in situ. The findings of a recent study suggest that stress fibers and its associated focal adhesions play roles in mechano-signal transduction mechanism. Stress fibers are present along the apical and the basal portion of the endothelial cells. Endothelial cells respond to fluid shear stress and change their morphological characteristics in both their cell shape and cytoskeletal organization. Atherosclerosis is a common disease of the arteries and it occurs in areas around the branching site of blood vessels where the cells are exposed to low fluid shear stress. The organization of stress fibers and focal adhesions are strongly influenced by shear stress, and therefore the generation of atherosclerotic lesions seem to be associated with the cytoskeletal components of endothelial cells. This review describes the possible role of the cytoskeleton as a mechano-transducer in endothelial cells in situ.
流体剪切应力是由血流产生的机械力，原位施加于内皮细胞的顶端表面。最近一项研究的结果表明，应力纤维及其相关的粘着斑在机械信号转导机制中发挥作用。应力纤维存在于内皮细胞的顶端和基部。内皮细胞对流体剪切应力作出反应，并在细胞形状和细胞骨架组织方面改变其形态特征。动脉粥样硬化是一种常见的动脉疾病，发生在血管分支部位周围的区域，在这些区域细胞暴露于低流体剪切应力。应力纤维和粘着斑的组织受到剪切应力的强烈影响，因此动脉粥样硬化病变的产生似乎与内皮细胞的细胞骨架成分有关。本综述描述了细胞骨架作为原位内皮细胞机械转导器的可能作用。
