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[伴有小脑共济失调和面部感觉异常的外斜视性双侧核间性眼肌麻痹(WEBINO)综合征病例]

[Case of wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome with cerebellar ataxia and facial dysesthesia].

作者信息

Kadoya Masato, Onoue Hiroyuki, Kadoya Akiko, Higashihara Mana, Ikewaki Katsunori, Kaida Kenichi

机构信息

Department of Neurology and Anti-aging Medicine, National Defense Medical College.

出版信息

Rinsho Shinkeigaku. 2014;54(4):317-20. doi: 10.5692/clinicalneurol.54.317.

Abstract

We report an 85-year-old man presenting with wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome with cerebellar ataxia and facial dysesthesia. He experienced an abrupt onset of double vision and exotropia of the right eye with unsteady gait and dysesthesia around upper lip. He was admitted to our hospital ten days after the onset of the double vision. On admission, he presented with WEBINO, left limb ataxia, and dysesthesia around upper lip on the right side. His exotropia was prominent on the right side. Diffusion weighted images of MRI revealed a high intensity lesion in the paramedian pontine tegmentum involving bilateral medial longitudinal fasciculus (MLF), consistent with acute ischemic lesion. Four months after the onset, the WEBINO persisted, without cerebellar ataxia and facial dysesthesia. Putative lesions of the WEBINO, cerebellar ataxia and facial dysesthesia were bilateral MLF, left superior cerebellar peduncle and trigeminothalamic tract, respectively, which were broader than the MRI lesion. Neurological examination is critical for evaluation of accurate ischemic area.

摘要

我们报告了一名85岁男性,患有壁凝视性双侧核间性眼肌麻痹(WEBINO)综合征,伴有小脑共济失调和面部感觉异常。他突然出现复视和右眼外斜视,步态不稳,上唇周围感觉异常。在出现复视十天后入院。入院时,他表现为WEBINO、左侧肢体共济失调和右侧上唇周围感觉异常。他的右眼外斜视较为明显。MRI弥散加权成像显示脑桥被盖部正中旁有一个高强度病变,累及双侧内侧纵束(MLF),符合急性缺血性病变。发病四个月后,WEBINO仍然存在,无小脑共济失调和面部感觉异常。WEBINO、小脑共济失调和面部感觉异常的推定病变分别为双侧MLF、左侧小脑上脚和三叉丘脑束,范围比MRI病变更广泛。神经学检查对于评估准确的缺血区域至关重要。

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