University Hospital Birmingham, Birmingham, UK.
Anaesthesia. 2014 Aug;69(8):826-31. doi: 10.1111/anae.12677. Epub 2014 May 7.
The practice of checking the ability to mask ventilate before administering neuromuscular blocking drugs remains controversial. We prospectively evaluated the changes in the expired tidal volume during pressure-controlled ventilation (two-handed mask ventilation technique) as a surrogate marker to assess the ease of mask ventilation following administration of rocuronium. After informed consent, 125 patients were anaesthetised using a standard induction technique consisting of fentanyl, propofol and rocuronium, with anaesthesia then maintained with isoflurane in oxygen. The mean (SD) expired tidal volume before administration of rocuronium increased by 61 (13) ml at 2 min following onset of neuromuscular block (p < 0.001). This supports the concept that neuromuscular blockade induced by rocuronium facilitates mask ventilation.
在给予神经肌肉阻滞剂之前检查通气掩蔽能力的做法仍然存在争议。我们前瞻性地评估了压力控制通气期间（双手面罩通气技术）呼气潮气量的变化，作为评估罗库溴铵给药后面罩通气容易程度的替代标志物。在获得知情同意后，125 名患者使用芬太尼、丙泊酚和罗库溴铵的标准诱导技术进行麻醉，然后用异氟烷和氧气维持麻醉。罗库溴铵给药后 2 分钟，呼气潮气量平均（SD）增加 61（13）ml（p < 0.001）。这支持了罗库溴铵诱导的神经肌肉阻滞有助于面罩通气的概念。
