Kussman B, Shorten G, Uppington J, Comunale M E
Department of Anaesthesia and Critical Care, Beth Israel Hospital, Boston, MA, USA.
Br J Anaesth. 1997 Jul;79(1):122-4. doi: 10.1093/bja/79.1.122.
The speeds of onset of pancuronium, atracurium and vecuronium are increased by prior administration of magnesium sulphate. A prospective, randomized, double-blind, controlled, clinical study was performed to examine the effects of prior i.v. administration of magnesium sulphate 60 mg kg-1 on the neuromuscular blocking effects of rocuronium 0.6 mg kg-1 during isoflurane anaesthesia. Neuromuscular function was measured electromyographically (Relaxograph) in 30 patients who received either magnesium sulphate 60 mg kg-1 or normal saline, 1-min before rocuronium 0.6 mg kg-1. Mean onset times were similar in the two groups (magnesium sulphate 71 (SD 20) s; normal saline 75 (23) s), but times to initial, 10% and 25% recovery from neuromuscular block were significantly longer in the magnesium sulphate group (42.1 (16.3), 49.0 (12.4) and 56.5 (13.2) min, respectively) than in the saline group (25.1 (9.1), 33.0 (11.1) and 35.6 (13.2) min, respectively) (P < 0.05 in all three cases). Administration of magnesium sulphate was not associated with adverse haemodynamic effects. Prior administration of magnesium sulphate, under the study conditions described, prolonged rocuronium-induced neuromuscular block but did not increase speed of onset.
预先给予硫酸镁可加快泮库溴铵、阿曲库铵和维库溴铵的起效速度。进行了一项前瞻性、随机、双盲、对照临床研究，以检验在异氟烷麻醉期间预先静脉注射60mg/kg硫酸镁对0.6mg/kg罗库溴铵神经肌肉阻滞作用的影响。在30例患者中，于注射0.6mg/kg罗库溴铵前1分钟，通过肌电图（松弛仪）测量神经肌肉功能，这些患者分别接受了60mg/kg硫酸镁或生理盐水。两组的平均起效时间相似（硫酸镁组71（标准差20）秒；生理盐水组75（23）秒），但硫酸镁组从神经肌肉阻滞中初始恢复、恢复10%和25%的时间明显长于生理盐水组（分别为42.1（16.3）、49.0（12.4）和56.5（13.2）分钟）（生理盐水组分别为25.（9.1）、33.0（11.1）和35.6（13.2）分钟）（所有三种情况P<0.05）。给予硫酸镁未产生不良血流动力学影响。在所述研究条件下，预先给予硫酸镁可延长罗库溴铵引起的神经肌肉阻滞，但未加快起效速度。
