Elsayed Mossad, Elkomy Ashraf, Aboubakr Mohamed, Morad Mohamed
Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Qalyubia 13736, Egypt.
Vet Med Int. 2014;2014:502872. doi: 10.1155/2014/502872. Epub 2014 Apr 3.
The aim of this study was to determine the blood and tissue concentrations profile and effect of tilmicosin on some hematological and biochemical parameters in broiler chicken. Fifty clinically healthy Hubbard chickens were orally administered 25 mg/kg BW of tilmicosin once daily for 5 consecutive days. Tissue residues of tilmicosin in slaughtered healthy chicken could not be detected by microbiological assay in all tested tissues except in lung (at 96 hours) and liver and kidneys (at 72 hours) after last administration. Tilmicosin caused temporary decrease in the RBCs and WBCs counts and has no effect on hemoglobin (Hb) and packed cell volume concentration (PCV). Also, the effect of tilmicosin on some biochemical parameters was as follows: the concentrations of creatinine, uric acid, electrolytes (sodium, potassium, and calcium), glucose, AST, ALT, ALP, and HDL-cholesterol in the serum of treated chicken did not change in response to the repeated oral administration of tilmicosin. There were only a temporary significant decrease in total protein and albumin concentrations and a significant increase in cholesterol and triglycerides concentrations. Chicken must not be slaughtered before 4 days from the stopping of tilmicosin administration. Tilmicosin makes temporary changes on hematological and biochemical parameters in broiler chicken.
本研究的目的是确定替米考星在肉鸡体内的血液和组织浓度分布情况，以及其对肉鸡一些血液学和生化参数的影响。选取50只临床健康的哈伯德肉鸡，连续5天每天口服25mg/kg体重的替米考星。末次给药后，除肺（96小时）、肝脏和肾脏（72小时）外，在所有检测组织中均未通过微生物学检测法检测到屠宰后健康鸡体内的替米考星组织残留。替米考星导致红细胞和白细胞计数暂时下降，对血红蛋白（Hb）和血细胞比容浓度（PCV）无影响。此外，替米考星对一些生化参数的影响如下：经反复口服替米考星后，处理组鸡血清中的肌酐、尿酸、电解质（钠、钾和钙）、葡萄糖、谷草转氨酶（AST）、谷丙转氨酶（ALT）、碱性磷酸酶（ALP）和高密度脂蛋白胆固醇（HDL-胆固醇）浓度未发生变化。仅总蛋白和白蛋白浓度出现暂时显著下降，胆固醇和甘油三酯浓度显著升高。在停止使用替米考星4天内不得屠宰肉鸡。替米考星会使肉鸡的血液学和生化参数发生暂时变化。
