Tartar Danielle, Bhutani Tina, Huynh Monica, Berger Timothy, Koo John
J Drugs Dermatol. 2014 May;13(5):564-8.
Phototherapy is often used to treat inflammatory skin conditions such as psoriasis and eczema. Much progress has recently been made in understanding the mechanisms underlying the local, cutaneous immune effects induced by phototherapy. Unlike many immunosuppressive drugs used in the management of inflammatory skin disease, phototherapy not only targets effector immune cells but also appears to up-regulate regulatory T cells (Tregs). Additionally, phototherapy reverses epidermal barrier abnormalities common in these diseases, allowing for restoration of cutaneous homeostasis.
光疗常用于治疗银屑病和湿疹等炎症性皮肤病。最近在理解光疗诱导的局部皮肤免疫效应的潜在机制方面取得了很大进展。与许多用于治疗炎症性皮肤病的免疫抑制药物不同，光疗不仅靶向效应免疫细胞，而且似乎还能上调调节性T细胞（Tregs）。此外，光疗可逆转这些疾病中常见的表皮屏障异常，从而恢复皮肤内环境稳定。
