Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Department of Dermatology, Research Unit for Photodermatology, Medical University of Graz, Auenbruggerplatz 8, Graz A-8036, Austria.
Dermatol Clin. 2020 Jan;38(1):37-53. doi: 10.1016/j.det.2019.08.004.
Phototherapeutic modalities induce apoptosis of keratinocytes and immune cells, impact cytokine production, downregulate the IL-23/Th17 axis, and induce regulatory T cells. As in anti-IL-17 or anti-IL-23 antibody treatment, the dual action of phototherapy on skin and the immune system is likely responsible for sustained resolution of lesions in diseases such as psoriasis. In cutaneous T cell lymphoma, phototherapy may function by causing tumor cell apoptosis and eliminating the neoplastic and inflammatory infiltrate. Further research on phototherapeutic mechanisms will help advance, optimize, and refine dermatologic treatments and may open up novel avenues for treatment strategies in dermatology and beyond.
光疗方法可诱导角质形成细胞和免疫细胞凋亡，影响细胞因子的产生，下调 IL-23/Th17 轴，并诱导调节性 T 细胞。与抗 IL-17 或抗 IL-23 抗体治疗一样，光疗对皮肤和免疫系统的双重作用可能是导致银屑病等疾病皮损持续缓解的原因。在皮肤 T 细胞淋巴瘤中，光疗可能通过诱导肿瘤细胞凋亡和消除肿瘤和炎症浸润来发挥作用。对光疗机制的进一步研究将有助于推进、优化和完善皮肤科治疗方法，并可能为皮肤科及其他领域的治疗策略开辟新途径。
