Weber Teresa M, Herndon James H, Ewer Melissa, Stephens Thomas J, Flick Iris, Filbry Alexander, Neufang Gitta, Schoelermann Andrea M
Teresa M. Weber, PhD, U.S. Research and Development, Beiersdorf, Inc., Wilton, CT.
J Dermatol Nurses Assoc. 2015 Jan;7(1):17-24. doi: 10.1097/JDN.0000000000000101.
Two steroid-free, over-the-counter skin protectant products have been developed for the care and treatment of atopic dermatitis (AD)-Eucerin Eczema Relief Body Crème (Body Cream) for daily skin moisturization and Eucerin Eczema Relief Instant Therapy cream (Instant Therapy) for treatment of AD flare-ups. We tested the efficacy and tolerability of these formulations in infants and children with AD.
Study 1: Body Cream was applied twice daily to the lower legs of 64 children with a history of AD (aged 3 months to 12 years) for 14 days. Study 2: Instant Therapy was applied to active lesions and surrounding skin of 29 children (aged 3 months to 12 years) with active atopic lesions. Assessments were performed at baseline and Days 7 and 14. Symptoms were assessed using the Atopic Dermatitis Severity Index in Study 2.
Body Cream significantly improved skin hydration and reduced itching, burning/stinging, erythema, and tactile roughness. Instant Therapy significantly improved skin hydration and AD symptoms, notably pruritus, erythema, and lichenification. Both products were safe and well tolerated.
Body Cream and Instant Therapy were effective and well tolerated in the treatment of AD in children. These products provide steroid-free, nonprescription therapy for the maintenance and treatment of acute eczema and were proven effective and safe in infants as young as 3 months.
已研发出两种不含类固醇的非处方皮肤保护产品，用于特应性皮炎（AD）的护理和治疗——优色林舒缓湿疹身体乳（身体乳）用于日常皮肤保湿，优色林舒缓湿疹即时护理霜（即时护理霜）用于治疗AD发作。我们测试了这些制剂在患有AD的婴幼儿和儿童中的疗效和耐受性。
研究1：对64名有AD病史（年龄3个月至12岁）的儿童的小腿每天涂抹两次身体乳，共14天。研究2：对29名有活动性特应性皮损（年龄3个月至12岁）的儿童的活动性皮损及周围皮肤涂抹即时护理霜。在基线以及第7天和第14天进行评估。在研究2中使用特应性皮炎严重程度指数评估症状。
身体乳显著改善了皮肤水合作用，减轻了瘙痒、灼痛/刺痛、红斑和触感粗糙。即时护理霜显著改善了皮肤水合作用和AD症状，尤其是瘙痒、红斑和苔藓化。两种产品均安全且耐受性良好。
身体乳和即时护理霜在治疗儿童AD方面有效且耐受性良好。这些产品为急性湿疹的维持和治疗提供了不含类固醇的非处方疗法，并且在3个月大的婴儿中被证明是有效且安全的。
