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Alpha-interferon therapy for lymphoproliferative disorders developing in two children following bone marrow transplants.

作者信息

Trigg M E, de Alarcon P, Rumelhart S, Holida M, Giller R

机构信息

Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City 52242.

出版信息

J Biol Response Mod. 1989 Dec;8(6):603-13.

PMID:2480993
Abstract

Two children developed lymphoproliferative processes following marrow transplantation. One of the two lymphoproliferative processes was documented to be Epstein-Barr virus (EBV)-associated. Both children received an extended course of alpha-interferon and gammaglobulin and responded with the disappearance of the lymphoproliferative process. Side effects from the alpha-interferon were minimal. Previous experience with EBV-associated lymphoproliferative processes following marrow transplantation have been usually fatal. This report further substantiates that alpha-interferon has a role in the treatment of EBV-associated lymphoproliferative processes following marrow transplantation.

摘要

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