Gordon Diandra K, Ponder Erinn N, Berrey B Hudson, Kubik Melanie J, Sindone Joseph
Department of Podiatric Medicine, The University of Florida & U/F Health Jacksonville Medical Center, United States.
The Department of Orthopaedic Surgery & Rehabilitation, The University of Florida & U/F Health Jacksonville Medical Center, United States.
Foot (Edinb). 2014 Jun;24(2):94-8. doi: 10.1016/j.foot.2014.03.009. Epub 2014 Apr 3.
Verrucous carcinoma of the foot is often misdiagnosed initially as plantar warts. Delayed diagnostic treatments with the use of optimal biopsy techniques may result in significant hindrances for patient care and may often result in detrimental outcomes to the patient. With the use of various epidermal biopsy methods, early diagnostic treatment can be implemented to a slow-growing lesion unresponsive to topical agents preventing unfavorable pedal amputations.
A case study of verrucous carcinoma of the foot with surgical resection was conducted along with a literature review.
Verrucous carcinoma (VC) of the foot is known to be a rare, locally invasive, well-differentiated low-grade squamous cell carcinoma that may evolve from the human papilloma virus. This localized tumor of the foot often has low metastatic potential, however can be quite invasive. It is therefore pertinent to obtain adequate radiological studies when planning for surgical resection of this tumor. When localized to the foot, it often involves deep structures such as tendons, muscle & bone. Complete wide local excision of the tumor is essential to avoid recurrence. We present a case of verrucous carcinoma of the foot in a 46-year-old African American male with a past medical history of Human immunodeficiency virus (HIV) and Human papilloma virus (HPV). The patient refused a Transmetatarsal amputation. The loss of the third digit was a result of tissue loss following resection and an attempt to relocate a severely laterally dislocated 3rd digit, not PVD.
足部疣状癌最初常被误诊为跖疣。使用最佳活检技术进行延迟诊断治疗可能会给患者护理带来重大阻碍，并常常给患者带来有害后果。通过使用各种表皮活检方法，可以对生长缓慢且对局部用药无反应的病变实施早期诊断治疗，从而避免不利的足部截肢。
对足部疣状癌进行手术切除的病例研究，并进行文献综述。
足部疣状癌（VC）是一种罕见的、局部侵袭性、高分化的低级别鳞状细胞癌，可能由人乳头瘤病毒演变而来。这种足部局限性肿瘤通常转移潜力低，但具有相当的侵袭性。因此，在计划对该肿瘤进行手术切除时，进行充分的放射学检查是很有必要的。当局限于足部时，它通常会累及肌腱、肌肉和骨骼等深部结构。完整广泛地局部切除肿瘤对于避免复发至关重要。我们报告一例46岁非裔美国男性足部疣状癌病例，该患者有人类免疫缺陷病毒（HIV）和人乳头瘤病毒（HPV）病史。患者拒绝经跖骨截肢。第三趾缺失是切除术后组织缺失以及试图复位严重外侧脱位的第三趾的结果，而非外周血管疾病（PVD）。
