Edmondson E F, Bright J M, Halsey C H, Ehrhart E J
Department of Microbiology Immunology and Pathology, Flint Animal Cancer Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Vet Pathol. 2015 Mar;52(2):338-43. doi: 10.1177/0300985814533805. Epub 2014 May 8.
Pheochromocytoma-associated catecholamine-induced cardiomyopathy is a well-known entity in man, nonhuman primates, and mice but has not been described in dogs. In this retrospective study, 9 dogs were identified with pheochromocytomas and concurrent cardiovascular pathology observed histologically (n = 6), echocardiographically (n = 4), and/or electrocardiographically (n = 5). Cardiac lesions included multifocal cardiomyocyte necrosis with contraction bands, cardiomyocyte degeneration, myocardial hemorrhage, lymphohistiocytic myocarditis, and interstitial fibrosis. Clinical procedures, including electrocardiographic and echocardiographic examinations, Doppler blood pressure measurement, and auscultation, were available for 5 dogs and consistently revealed concentric or mixed (eccentric and concentric) ventricular hypertrophy. Additional changes observed included arrhythmias, systemic hypertension, and heart murmurs. The myocardial lesions observed in this series of dogs are similar to those observed in humans with pheochromocytoma-associated catecholamine-induced cardiomyopathy. Since the clinical manifestations of catecholamine-induced cardiac disease are amenable to medical treatment, recognition of this cardiomyopathy has the potential to reduce morbidity and mortality in dogs with pheochromocytoma.
嗜铬细胞瘤相关的儿茶酚胺诱导性心肌病在人类、非人灵长类动物和小鼠中是一种已知的病症，但在犬类中尚未见报道。在这项回顾性研究中，确定了9只患有嗜铬细胞瘤且同时伴有经组织学检查（n = 6）、超声心动图检查（n = 4）和/或心电图检查（n = 5）观察到的心血管病变的犬。心脏病变包括伴有收缩带的多灶性心肌细胞坏死、心肌细胞变性、心肌出血、淋巴细胞性心肌炎和间质纤维化。5只犬可进行包括心电图和超声心动图检查、多普勒血压测量及听诊在内的临床检查，结果一致显示为向心性或混合性（离心性和向心性）心室肥厚。观察到的其他变化包括心律失常、全身性高血压和心脏杂音。这一系列犬中观察到的心肌病变与人类嗜铬细胞瘤相关的儿茶酚胺诱导性心肌病中观察到的病变相似。由于儿茶酚胺诱导性心脏病的临床表现适合药物治疗，识别这种心肌病有可能降低患有嗜铬细胞瘤的犬的发病率和死亡率。
