Asproni P, Vignoli M, Cancedda S, Millanta F, Terragni R, Poli A
Dipartimento di Scienze Veterinarie, University of Pisa, Pisa I-56124, Italy.
Centro Oncologico Veterinario, Via San Lorenzo 1/4, 40037 Sasso Marconi, Bologna, Italy.
J Comp Pathol. 2014 Jul;151(1):35-41. doi: 10.1016/j.jcpa.2014.03.008. Epub 2014 Mar 29.
There is much interest in the potential use of selective inhibitors of cyclooxygenase (COX)-2 in combination with other cancer therapeutics. COX-2 is a key enzyme in prostaglandin synthesis and has been implicated in the pathogenesis of numerous canine and feline malignancies. There are few data on the potential role of COX-2 in the pathogenesis of canine lymphoma. The present study examined COX-2 expression in normal, hyperplastic and neoplastic canine lymphoid tissues. Immunohistochemical expression was evaluated in 12 samples of non-pathologically enlarged normal lymph nodes, 24 samples of hyperplastic lymph node and 44 samples of lymphoma (22 B-cell and 22 T-cell lymphomas). The labelling was scored semiquantitatively and a score of +2 or +3 was interpreted as overexpression. In hyperplastic lymph nodes only a few macrophages were COX-2-positive while six of the 44 lymphomas (13.6%; three B- and three T-cell lymphomas) overexpressed COX-2. These data provide a rationale for further investigation of COX-2 expression in canine lymphoma for prognostic, chemopreventive and chemotherapeutic purposes.
人们对环氧化酶（COX）-2选择性抑制剂与其他癌症治疗方法联合使用的潜在用途非常感兴趣。COX-2是前列腺素合成中的关键酶，并且与许多犬猫恶性肿瘤的发病机制有关。关于COX-2在犬淋巴瘤发病机制中的潜在作用的数据很少。本研究检测了正常、增生性和肿瘤性犬淋巴组织中COX-2的表达。对12份非病理性肿大的正常淋巴结样本、24份增生性淋巴结样本和44份淋巴瘤样本（22份B细胞淋巴瘤和22份T细胞淋巴瘤）进行了免疫组化表达评估。对标记进行半定量评分，+2或+3分被解释为过表达。在增生性淋巴结中，只有少数巨噬细胞COX-2呈阳性，而44份淋巴瘤中有6份（13.6%；3份B细胞淋巴瘤和3份T细胞淋巴瘤）过表达COX-2。这些数据为进一步研究COX-2在犬淋巴瘤中的表达以用于预后、化学预防和化疗目的提供了理论依据。
