Immunohistochemical expression of cyclooxygenase-2 in canine ovarian carcinomas.
作者信息
Borzacchiello G, Russo V, Russo M
机构信息
Department of Pathology and Animal Health, General Pathology and Anatomic Pathology Division, Faculty of Veterinary Medicine, University of Naples Federico II Via F. Delpino, 1-80137 Naples, Italy.
出版信息
J Vet Med A Physiol Pathol Clin Med. 2007 Jun;54(5):247-9. doi: 10.1111/j.1439-0442.2007.00934.x.
Ovarian tumours among domestic animals are frequently encountered in bitch. Cyclooxygenase-2 (COX-2) expression has been evaluated in different kind of canine primary epithelial neoplasms. Eleven canine ovarian carcinomas and two normal samples were evaluated immunohistochemically for COX-2 expression. Nine of 11 carcinoma samples (81%) expressed COX-2 enzyme isoform. The immunoreactivity was intracytoplasmically recorded and the intensity ranged from faint to strong. Our results show that COX-2 is expressed in canine ovarian carcinoma, suggesting a potential role of COX-2 in canine ovarian carcinogenesis.
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